Dissociable roles of ventromedial prefrontal cortex (vmPFC) and rostral anterior cingulate cortex (rACC) in value representation and optimistic bias

Karina Blair, Marcela Otero, Cindy Teng, Madeline Jacobs, Stephanie Odenheimer, Daniel S. Pine, Robert James Blair

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Optimistic bias (OB) is seen when individuals underestimate their probability of experiencing negative life events and overestimate their probability of experiencing positive life events. A reduced OB has been linked with increased depression symptoms. However, given the relevance of this information to mood and anxiety disorders, little is currently known regarding the neurobiology of OB. In the current study, we examine the neural basis of OB in healthy individuals (n. =. 33) during probability estimation of future positive and negative events occurring to themselves relative to other, comparable individuals. In line with previous work, subjects showed significant OB; they considered themselves significantly more likely to experience future positive and significantly less likely to experience future negative events relative to comparable others. Positive, relative to negative events, un-modulated by subjects' probability estimates, were associated with significantly greater activity within the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Moreover, responses within both regions to positive events negatively related to the healthy subjects' self reports of depression symptoms. However, there was no significant modulation of activity in either region by the subject's OB, objectified as the level to which they thought the event was more likely [positive events] or less likely [negative events] to occur to them relative to comparable others. In contrast, activity within the rostral anterior cingulate cortex (rACC) was positively modulated by OB for positive events and activity within the anterior insula and dorsomedial prefrontal cortex (dmPFC) was negatively modulated by OB for negative events. However, there was no significant relationship between responsiveness within these regions and self reports of depression symptoms. The data are discussed with reference to current models of vmPFC, rACC and anterior insula functioning.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalNeuroImage
Volume78
DOIs
StatePublished - Sep 1 2013

Fingerprint

Gyrus Cinguli
Prefrontal Cortex
Depression
Self Report
Neurobiology
Anxiety Disorders
Mood Disorders
Healthy Volunteers

Keywords

  • FMRI
  • Optimistic bias
  • Rostral anterior cingulate cortex
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Dissociable roles of ventromedial prefrontal cortex (vmPFC) and rostral anterior cingulate cortex (rACC) in value representation and optimistic bias. / Blair, Karina; Otero, Marcela; Teng, Cindy; Jacobs, Madeline; Odenheimer, Stephanie; Pine, Daniel S.; Blair, Robert James.

In: NeuroImage, Vol. 78, 01.09.2013, p. 103-110.

Research output: Contribution to journalArticle

Blair, Karina ; Otero, Marcela ; Teng, Cindy ; Jacobs, Madeline ; Odenheimer, Stephanie ; Pine, Daniel S. ; Blair, Robert James. / Dissociable roles of ventromedial prefrontal cortex (vmPFC) and rostral anterior cingulate cortex (rACC) in value representation and optimistic bias. In: NeuroImage. 2013 ; Vol. 78. pp. 103-110.
@article{9b20dfbd6d0b45c689c73fb44809ebbd,
title = "Dissociable roles of ventromedial prefrontal cortex (vmPFC) and rostral anterior cingulate cortex (rACC) in value representation and optimistic bias",
abstract = "Optimistic bias (OB) is seen when individuals underestimate their probability of experiencing negative life events and overestimate their probability of experiencing positive life events. A reduced OB has been linked with increased depression symptoms. However, given the relevance of this information to mood and anxiety disorders, little is currently known regarding the neurobiology of OB. In the current study, we examine the neural basis of OB in healthy individuals (n. =. 33) during probability estimation of future positive and negative events occurring to themselves relative to other, comparable individuals. In line with previous work, subjects showed significant OB; they considered themselves significantly more likely to experience future positive and significantly less likely to experience future negative events relative to comparable others. Positive, relative to negative events, un-modulated by subjects' probability estimates, were associated with significantly greater activity within the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Moreover, responses within both regions to positive events negatively related to the healthy subjects' self reports of depression symptoms. However, there was no significant modulation of activity in either region by the subject's OB, objectified as the level to which they thought the event was more likely [positive events] or less likely [negative events] to occur to them relative to comparable others. In contrast, activity within the rostral anterior cingulate cortex (rACC) was positively modulated by OB for positive events and activity within the anterior insula and dorsomedial prefrontal cortex (dmPFC) was negatively modulated by OB for negative events. However, there was no significant relationship between responsiveness within these regions and self reports of depression symptoms. The data are discussed with reference to current models of vmPFC, rACC and anterior insula functioning.",
keywords = "FMRI, Optimistic bias, Rostral anterior cingulate cortex, Ventromedial prefrontal cortex",
author = "Karina Blair and Marcela Otero and Cindy Teng and Madeline Jacobs and Stephanie Odenheimer and Pine, {Daniel S.} and Blair, {Robert James}",
year = "2013",
month = "9",
day = "1",
doi = "10.1016/j.neuroimage.2013.03.063",
language = "English (US)",
volume = "78",
pages = "103--110",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Dissociable roles of ventromedial prefrontal cortex (vmPFC) and rostral anterior cingulate cortex (rACC) in value representation and optimistic bias

AU - Blair, Karina

AU - Otero, Marcela

AU - Teng, Cindy

AU - Jacobs, Madeline

AU - Odenheimer, Stephanie

AU - Pine, Daniel S.

AU - Blair, Robert James

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Optimistic bias (OB) is seen when individuals underestimate their probability of experiencing negative life events and overestimate their probability of experiencing positive life events. A reduced OB has been linked with increased depression symptoms. However, given the relevance of this information to mood and anxiety disorders, little is currently known regarding the neurobiology of OB. In the current study, we examine the neural basis of OB in healthy individuals (n. =. 33) during probability estimation of future positive and negative events occurring to themselves relative to other, comparable individuals. In line with previous work, subjects showed significant OB; they considered themselves significantly more likely to experience future positive and significantly less likely to experience future negative events relative to comparable others. Positive, relative to negative events, un-modulated by subjects' probability estimates, were associated with significantly greater activity within the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Moreover, responses within both regions to positive events negatively related to the healthy subjects' self reports of depression symptoms. However, there was no significant modulation of activity in either region by the subject's OB, objectified as the level to which they thought the event was more likely [positive events] or less likely [negative events] to occur to them relative to comparable others. In contrast, activity within the rostral anterior cingulate cortex (rACC) was positively modulated by OB for positive events and activity within the anterior insula and dorsomedial prefrontal cortex (dmPFC) was negatively modulated by OB for negative events. However, there was no significant relationship between responsiveness within these regions and self reports of depression symptoms. The data are discussed with reference to current models of vmPFC, rACC and anterior insula functioning.

AB - Optimistic bias (OB) is seen when individuals underestimate their probability of experiencing negative life events and overestimate their probability of experiencing positive life events. A reduced OB has been linked with increased depression symptoms. However, given the relevance of this information to mood and anxiety disorders, little is currently known regarding the neurobiology of OB. In the current study, we examine the neural basis of OB in healthy individuals (n. =. 33) during probability estimation of future positive and negative events occurring to themselves relative to other, comparable individuals. In line with previous work, subjects showed significant OB; they considered themselves significantly more likely to experience future positive and significantly less likely to experience future negative events relative to comparable others. Positive, relative to negative events, un-modulated by subjects' probability estimates, were associated with significantly greater activity within the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Moreover, responses within both regions to positive events negatively related to the healthy subjects' self reports of depression symptoms. However, there was no significant modulation of activity in either region by the subject's OB, objectified as the level to which they thought the event was more likely [positive events] or less likely [negative events] to occur to them relative to comparable others. In contrast, activity within the rostral anterior cingulate cortex (rACC) was positively modulated by OB for positive events and activity within the anterior insula and dorsomedial prefrontal cortex (dmPFC) was negatively modulated by OB for negative events. However, there was no significant relationship between responsiveness within these regions and self reports of depression symptoms. The data are discussed with reference to current models of vmPFC, rACC and anterior insula functioning.

KW - FMRI

KW - Optimistic bias

KW - Rostral anterior cingulate cortex

KW - Ventromedial prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=84877081144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877081144&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2013.03.063

DO - 10.1016/j.neuroimage.2013.03.063

M3 - Article

VL - 78

SP - 103

EP - 110

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -