Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene

J. A. Cunningham, J. D. Kellner, P. J. Bridge, C. L. Trevenen, D. R. McLeod, H. D. Davies

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymph-adenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-γR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.

Original languageEnglish (US)
Pages (from-to)791-794
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume4
Issue number8
StatePublished - Sep 6 2000

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Keywords

  • BCG
  • Immunodeficiency
  • Interferon-gamma receptor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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