Disparate metabolic responses in mice fed a high-fat diet supplemented with maize-derived non-digestible feruloylated oligoand polysaccharides are linked to changes in the gut microbiota

Junyi Yang, Laure B. Bindels, Rafael R.Segura Munoz, Inés Martínez, Jens Walter, Amanda Ramer-Tait, Devin J Rose

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Studies have suggested links between colonic fermentation of dietary fibers and improved metabolic health. The objectives of this study were to determine if non-digestible feruloylated oligo-And polysaccharides (FOPS), a maize-derived dietary fiber, could counteract the deleterious effects of high-fat (HF) feeding in mice and explore if metabolic benefits were linked to the gut microbiota. C57BL/6J mice (n = 8/group) were fed a low-fat (LF; 10 kcal% fat), HF (62 kcal% fat), or HF diet supplemented with FOPS (5%, w/w). Pronounced differences in FOPS responsiveness were observed: four mice experienced cecal enlargement and enhanced short chain fatty acid production, indicating increased cecal fermentation (F-FOPS). Only these mice displayed improvements in glucose metabolism compared with HF-fed mice. Blooms in the gut microbial genera Blautia and Akkermansia were observed in three of the F-FOPS mice; these shifts were associated with reductions in body and adipose tissue weights compared with the HF-fed control mice. No improvements in metabolic markers or weights were detected in the four mice whose gut microbiota did not respond to FOPS. These findings demonstrate that FOPS-induced improvements in weight gain and metabolic health in mice depended on the ability of an individual's microbiota to ferment FOPS.

Original languageEnglish (US)
Article numberA198
JournalPloS one
Volume11
Issue number1
DOIs
StatePublished - Jan 5 2016

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High Fat Diet
high fat diet
Nutrition
intestinal microorganisms
Zea mays
Polysaccharides
polysaccharides
Fats
corn
mice
lipids
Dietary Fiber
Fermentation
Health
dietary fiber
fermentation
Weights and Measures
Gastrointestinal Microbiome
Volatile Fatty Acids
Microbiota

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Disparate metabolic responses in mice fed a high-fat diet supplemented with maize-derived non-digestible feruloylated oligoand polysaccharides are linked to changes in the gut microbiota. / Yang, Junyi; Bindels, Laure B.; Munoz, Rafael R.Segura; Martínez, Inés; Walter, Jens; Ramer-Tait, Amanda; Rose, Devin J.

In: PloS one, Vol. 11, No. 1, A198, 05.01.2016.

Research output: Contribution to journalArticle

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abstract = "Studies have suggested links between colonic fermentation of dietary fibers and improved metabolic health. The objectives of this study were to determine if non-digestible feruloylated oligo-And polysaccharides (FOPS), a maize-derived dietary fiber, could counteract the deleterious effects of high-fat (HF) feeding in mice and explore if metabolic benefits were linked to the gut microbiota. C57BL/6J mice (n = 8/group) were fed a low-fat (LF; 10 kcal{\%} fat), HF (62 kcal{\%} fat), or HF diet supplemented with FOPS (5{\%}, w/w). Pronounced differences in FOPS responsiveness were observed: four mice experienced cecal enlargement and enhanced short chain fatty acid production, indicating increased cecal fermentation (F-FOPS). Only these mice displayed improvements in glucose metabolism compared with HF-fed mice. Blooms in the gut microbial genera Blautia and Akkermansia were observed in three of the F-FOPS mice; these shifts were associated with reductions in body and adipose tissue weights compared with the HF-fed control mice. No improvements in metabolic markers or weights were detected in the four mice whose gut microbiota did not respond to FOPS. These findings demonstrate that FOPS-induced improvements in weight gain and metabolic health in mice depended on the ability of an individual's microbiota to ferment FOPS.",
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