Discovering the route from inflammation to pancreatic cancer

N. Momi, Sukwinder Kaur, S. R. Krishn, Surinder Kumar Batra

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Pancreatic cancer (PC) remains a complex malignancy with the worst prognosis, lack of early diagnostic symptoms and resistance to conventional chemo- and radiotherapies. A better understanding of the etiology and early developmental events of PC requires profound attention. The evolution of fully blown PC from initial pancreatic injury is a multi-factorial phenomenon with a series of sequential events. The initial acute infection or tissue damage triggers inflammation that, in conjunction with innate immunity, establishes a state of homeostasis to limit harm to the body. Recurrent pancreatic injuries due to genetic susceptibility, smoking, unhealthy diet, and alcohol abuse induces a pro-inflammatory milieu, consisting of various types of immune cells, cytokines, chemokines, growth factors and restructured extracellular matrix, leading to prolonged inflammatory/chronic conditions. Cells having sustained DNA damage and/or mutagenic assault take advantage of this prolonged inflammatory response and aid in the initiation and development of neoplastic/fibrotic events. Eventually, many tumor-stromal interactions result in a chaotic environment accompanied by a loss of immune surveillance and repair response, thereby leading to PC. A better understanding of the inflammatory markers defining this "injury-inflammation-cancer" pathway would help to identify novel molecular targets for early screening and therapeutic intervention for this lethal malignancy.

Original languageEnglish (US)
Pages (from-to)283-297
Number of pages15
JournalMinerva Gastroenterologica e Dietologica
Volume58
Issue number4
StatePublished - Dec 1 2012

Fingerprint

Pancreatic Neoplasms
Inflammation
Neoplasms
Wounds and Injuries
Genetic Predisposition to Disease
Chemokines
Innate Immunity
Alcoholism
DNA Damage
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Homeostasis
Radiotherapy
Smoking
Cytokines
Diet
Drug Therapy
Infection
Therapeutics

Keywords

  • Inflammation
  • Neoplasms
  • Obesity
  • Pancreatic neoplasms
  • Pancreatitis
  • Smoking

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Gastroenterology

Cite this

Discovering the route from inflammation to pancreatic cancer. / Momi, N.; Kaur, Sukwinder; Krishn, S. R.; Batra, Surinder Kumar.

In: Minerva Gastroenterologica e Dietologica, Vol. 58, No. 4, 01.12.2012, p. 283-297.

Research output: Contribution to journalReview article

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