Disabling surveillance

Bacterial type III secretion system effectors that suppress innate immunity

Avelina Espinosa, James R Alfano

Research output: Contribution to journalShort survey

126 Citations (Scopus)

Abstract

Many Gram-negative bacterial pathogens of plants and animals are dependent on a type III protein secretion system (TTSS). TTSSs translocate effector proteins into host cells and are capable of modifying signal transduction pathways. The innate immune system of eukaryotes detects the presence of pathogens using specific pathogen recognition receptors (PRRs). Plant PRRs include the FLS2 receptor kinase and resistance proteins. Animal PRRs include Toll-like receptors and nucleotide-binding oligomerization domain proteins. PRRs initiate signal transduction pathways that include mitogen-activated protein kinase (MAPK) cascades that activate defence-related transcription factors. This results in induction of proinflammatory cytokines in animals, and hallmarks of defence in plants including the hypersensitive response, callose deposition and the production of pathogenesis-related proteins. Several type III effectors from animal and plant pathogens have evolved to counteract innate immunity. For example, the Yersinia YopJ/P cysteine protease and the Pseudomonas syringae HopPtoD2 protein tyrosine phosphatase inhibits defence-related MAPK kinase activity in animals and plants respectively. Thus, type III effectors can suppress signal transduction pathways activated by PRR surveillance systems. Understanding targets and activities of type III effectors will reveal much about bacterial pathogenicity and the innate immune system in plants and animals.

Original languageEnglish (US)
Pages (from-to)1027-1040
Number of pages14
JournalCellular Microbiology
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2004

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Pathogens
Innate Immunity
Animals
Signal transduction
Signal Transduction
Nod Signaling Adaptor Proteins
Immune system
Plant Immunity
Pseudomonas syringae
Yersinia
Proteins
Protein Tyrosine Phosphatases
Cysteine Proteases
Toll-Like Receptors
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Eukaryota
Protein Kinases
Oligomerization
Virulence

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Microbiology

Cite this

Disabling surveillance : Bacterial type III secretion system effectors that suppress innate immunity. / Espinosa, Avelina; Alfano, James R.

In: Cellular Microbiology, Vol. 6, No. 11, 01.11.2004, p. 1027-1040.

Research output: Contribution to journalShort survey

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