Direct retino-raphe projection alters serotonergic tone and affective behavior

Chaoran Ren, Liju Luan, Benson Wui-Man Lau, Xin Huang, Jian Yang, Yuan Zhou, Xihong Wu, Jie Gao, Gary E. Pickard, Kwok Fai So, Mingliang Pu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.

Original languageEnglish (US)
Pages (from-to)1163-1175
Number of pages13
JournalNeuropsychopharmacology
Volume38
Issue number7
DOIs
StatePublished - Jun 1 2013

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Retinal Ganglion Cells
Light
Serotonin
Immunotoxins
Visual Pathways
Fluoxetine
Serotonin Uptake Inhibitors
Dorsal Raphe Nucleus
Depression

Keywords

  • SSRI
  • affective visual information
  • depression
  • dorsal raphe nucleus
  • retinal ganglion cell

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Ren, C., Luan, L., Wui-Man Lau, B., Huang, X., Yang, J., Zhou, Y., ... Pu, M. (2013). Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology, 38(7), 1163-1175. https://doi.org/10.1038/npp.2013.35

Direct retino-raphe projection alters serotonergic tone and affective behavior. / Ren, Chaoran; Luan, Liju; Wui-Man Lau, Benson; Huang, Xin; Yang, Jian; Zhou, Yuan; Wu, Xihong; Gao, Jie; Pickard, Gary E.; So, Kwok Fai; Pu, Mingliang.

In: Neuropsychopharmacology, Vol. 38, No. 7, 01.06.2013, p. 1163-1175.

Research output: Contribution to journalArticle

Ren, C, Luan, L, Wui-Man Lau, B, Huang, X, Yang, J, Zhou, Y, Wu, X, Gao, J, Pickard, GE, So, KF & Pu, M 2013, 'Direct retino-raphe projection alters serotonergic tone and affective behavior', Neuropsychopharmacology, vol. 38, no. 7, pp. 1163-1175. https://doi.org/10.1038/npp.2013.35
Ren C, Luan L, Wui-Man Lau B, Huang X, Yang J, Zhou Y et al. Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology. 2013 Jun 1;38(7):1163-1175. https://doi.org/10.1038/npp.2013.35
Ren, Chaoran ; Luan, Liju ; Wui-Man Lau, Benson ; Huang, Xin ; Yang, Jian ; Zhou, Yuan ; Wu, Xihong ; Gao, Jie ; Pickard, Gary E. ; So, Kwok Fai ; Pu, Mingliang. / Direct retino-raphe projection alters serotonergic tone and affective behavior. In: Neuropsychopharmacology. 2013 ; Vol. 38, No. 7. pp. 1163-1175.
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