Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

Craig T. Morita, Evan M. Beckman, Jack F. Bukowski, Yoshimasa Tanaka, Hamid Band, Barry R. Bloom, David E. Golan, Michael B. Brenner

Research output: Contribution to journalArticle

390 Citations (Scopus)

Abstract

Human Vγ2Vδ2+ T cells recognize mycobacterial non-peptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. Vγ2Vδ2+ T cells recognized secreted prenyl pyrophosphate antigens in the absence of other accessory cells but, under such conditions, required T cell-T cell contact. Recognition required neither the expression of classical MHC class I, MHC class II, or CD1a, CD1b, and CD1c molecules, nor MHC class I or class II peptide loading pathways. Fixed accessory cells also presented the prenyl pyrophosphate antigens to γδ T cells. Thus, in contrast with the presentation of conventional peptide antigens, protein antigens, and superantigens to αβ T cells, prenyl pyrophosphate antigens are presented to γδ T cells through a novel extracellular pathway that does not require antigen uptake, antigen processing, or MHC class I or class II expression. This pathway allows for the rapid recognition of bacteria by γδ T cells and suggests that γδ T cells play a role in the early response to bacterial infection.

Original languageEnglish (US)
Pages (from-to)495-507
Number of pages13
JournalImmunity
Volume3
Issue number4
DOIs
StatePublished - Oct 1995

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T-Lymphocytes
Antigens
Antigen Presentation
diphosphoric acid
prenyl
Superantigens
Peptides
Bacterial Infections
Bacteria
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Morita, C. T., Beckman, E. M., Bukowski, J. F., Tanaka, Y., Band, H., Bloom, B. R., ... Brenner, M. B. (1995). Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity, 3(4), 495-507. https://doi.org/10.1016/1074-7613(95)90178-7

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. / Morita, Craig T.; Beckman, Evan M.; Bukowski, Jack F.; Tanaka, Yoshimasa; Band, Hamid; Bloom, Barry R.; Golan, David E.; Brenner, Michael B.

In: Immunity, Vol. 3, No. 4, 10.1995, p. 495-507.

Research output: Contribution to journalArticle

Morita, CT, Beckman, EM, Bukowski, JF, Tanaka, Y, Band, H, Bloom, BR, Golan, DE & Brenner, MB 1995, 'Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells', Immunity, vol. 3, no. 4, pp. 495-507. https://doi.org/10.1016/1074-7613(95)90178-7
Morita, Craig T. ; Beckman, Evan M. ; Bukowski, Jack F. ; Tanaka, Yoshimasa ; Band, Hamid ; Bloom, Barry R. ; Golan, David E. ; Brenner, Michael B. / Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. In: Immunity. 1995 ; Vol. 3, No. 4. pp. 495-507.
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