Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging

Thomas R. Porter, David O. Taylor, Jennifer Fields, Alan Cycan, Kwame Akosah, Pramod K. Mohanty, Natesa G. Pandian

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Abstract

Patients with chronic congestive heart failure (CHF) frequently develop secondary pulmonary hypertension. This development is a poor prognostic indicator.1 In addition, secondary pulmonary hypertension that does not improve in response to vasodilators identifies a group of patients who will have a poor outcome after orthotopic heart transplantation.2,3 The structural abnormalities of the pulmonary artery that occur in CHF have been described in autopsy specimens,4 and human studies have demonstrated indirectly that there are alterations in pulmonary vascular impedance and stiffness.5,6 Intravascular ultrasound using high-frequency catheter-based imaging has been performed to quantify pulmonary artery area and diameter in humans.7 It also has been validated as a method of detecting plaque in both elastic and muscular arteries.8 We hypothesized that intravascular ultrasound could be used to characterize the changes in pulmonary vascular morphology and elasticity in CHF.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalThe American Journal of Cardiology
Volume71
Issue number8
DOIs
StatePublished - Mar 15 1993

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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