Direct evidence for the presence of a different converting enzyme in the hamster cheek pouch

K. G. Cornish, W. L. Joyner, J. P. Gilmore

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Kininase II (angiotensin I-converting enzyme) is generally accepted to be the enzyme responsible for the conversion of angiotensin I (A I) to angiotensin (A II). This study examined the response of the microvasculature of the hamster cheek pouch to the local application of A I, A II, and the renin substrate, tetradecapeptide (TDP). A I and TDP caused a localized vasoconstriction that was not blocked by converting enzyme inhibitors (CEI; BPF(5a) for A I and BPF(5a) and the nonapeptide inhibitor for TDP. However, both the A II antagonist [Sar1, Ala8]angiotensin II and the antiserum to A II blocked completely the A I- and TDP-induced vasoconstriction. Sixty-eight percent of the applied A I was converted to A II in the presence of CEI as well as in its absence. It is concluded that the vasculature of the hamster cheek pouch converts significant amounts of A I to A II by a route that does not involve kininase II.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalCirculation Research
Volume44
Issue number4
DOIs
StatePublished - Jan 1 1979

Fingerprint

Angiotensin I
Cheek
Cricetinae
Angiotensins
Enzymes
Peptidyl-Dipeptidase A
Vasoconstriction
Angiotensinogen
Enzyme Inhibitors
Microvessels
Angiotensin II
Immune Sera

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Direct evidence for the presence of a different converting enzyme in the hamster cheek pouch. / Cornish, K. G.; Joyner, W. L.; Gilmore, J. P.

In: Circulation Research, Vol. 44, No. 4, 01.01.1979, p. 540-544.

Research output: Contribution to journalArticle

Cornish, K. G. ; Joyner, W. L. ; Gilmore, J. P. / Direct evidence for the presence of a different converting enzyme in the hamster cheek pouch. In: Circulation Research. 1979 ; Vol. 44, No. 4. pp. 540-544.
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