Dilazep-induced vasodilation is mediated through adenosine receptors

Yong Zhang, Jonathan D. Geiger, Dallas J. Légaré, W. Wayne Lautt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.

Original languageEnglish (US)
Pages (from-to)PL129-PL133
JournalLife Sciences
Volume49
Issue number18
DOIs
Publication statusPublished - 1991

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this