Diffusion in heterogeneous media

Application to immobilized cell systems

Mark Riley, Fernando J. Muzzio, Helen M. Buettner, Sebastian C. Reyes

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Transport of small molecules in heterogeneous materials can be an important factor in many engineering and biological applications. This study focuses on the diffusion of cellular nutrients in an immobilized cell system. A Monte Carlo simulation technique is used to describe the diffusion of small molecules in a variety of simulated cellular structures. Diffusivity predictions are in close agreement with experimental values as well as with theoretical bounds reported in the literature. It is revealed that effective diffusivities are highly dependent on the diffusivities of the species in the various phases and on the volume fraction of cells. The spatial arrangement of the cells, however, has no apparent effect on the predicted diffusivity for the range of conditions investigated.

Original languageEnglish (US)
Pages (from-to)691-700
Number of pages10
JournalAIChE Journal
Volume41
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Immobilized Cells
Cells
Bioengineering
Cellular Structures
Cell Size
Food
Molecules
Nutrients
Volume fraction

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)

Cite this

Diffusion in heterogeneous media : Application to immobilized cell systems. / Riley, Mark; Muzzio, Fernando J.; Buettner, Helen M.; Reyes, Sebastian C.

In: AIChE Journal, Vol. 41, No. 3, 01.01.1995, p. 691-700.

Research output: Contribution to journalArticle

Riley, Mark ; Muzzio, Fernando J. ; Buettner, Helen M. ; Reyes, Sebastian C. / Diffusion in heterogeneous media : Application to immobilized cell systems. In: AIChE Journal. 1995 ; Vol. 41, No. 3. pp. 691-700.
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