Diffusion basis spectrum imaging for identifying pathologies in MS subtypes

Afsaneh Shirani, Peng Sun, Kathryn Trinkaus, Dana C. Perantie, Ajit George, Robert T. Naismith, Robert E. Schmidt, Sheng Kwei Song, Anne H. Cross

Research output: Contribution to journalArticle

Abstract

Diffusion basis spectrum imaging (DBSI) combines discrete anisotropic diffusion tensors and the spectrum of isotropic diffusion tensors to model the underlying multiple sclerosis (MS) pathologies. We used clinical MS subtypes as a surrogate of underlying pathologies to assess DBSI as a biomarker of pathology in 55 individuals with MS. Restricted isotropic fraction (reflecting cellularity) and fiber fraction (representing apparent axonal density) were the most important DBSI metrics to classify MS using brain white matter lesions. These DBSI metrics outperformed lesion volume. When analyzing the normal-appearing corpus callosum, the most significant DBSI metrics were fiber fraction, radial diffusivity (reflecting myelination), and nonrestricted isotropic fraction (representing edema). This study provides preliminary evidence supporting the ability of DBSI as a potential noninvasive biomarker of MS neuropathology.

Original languageEnglish (US)
Pages (from-to)2323-2327
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2019

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Multiple Sclerosis
Pathology
Biomarkers
Corpus Callosum
Edema
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Shirani, A., Sun, P., Trinkaus, K., Perantie, D. C., George, A., Naismith, R. T., ... Cross, A. H. (2019). Diffusion basis spectrum imaging for identifying pathologies in MS subtypes. Annals of Clinical and Translational Neurology, 6(11), 2323-2327. https://doi.org/10.1002/acn3.50903

Diffusion basis spectrum imaging for identifying pathologies in MS subtypes. / Shirani, Afsaneh; Sun, Peng; Trinkaus, Kathryn; Perantie, Dana C.; George, Ajit; Naismith, Robert T.; Schmidt, Robert E.; Song, Sheng Kwei; Cross, Anne H.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 11, 01.11.2019, p. 2323-2327.

Research output: Contribution to journalArticle

Shirani, A, Sun, P, Trinkaus, K, Perantie, DC, George, A, Naismith, RT, Schmidt, RE, Song, SK & Cross, AH 2019, 'Diffusion basis spectrum imaging for identifying pathologies in MS subtypes', Annals of Clinical and Translational Neurology, vol. 6, no. 11, pp. 2323-2327. https://doi.org/10.1002/acn3.50903
Shirani, Afsaneh ; Sun, Peng ; Trinkaus, Kathryn ; Perantie, Dana C. ; George, Ajit ; Naismith, Robert T. ; Schmidt, Robert E. ; Song, Sheng Kwei ; Cross, Anne H. / Diffusion basis spectrum imaging for identifying pathologies in MS subtypes. In: Annals of Clinical and Translational Neurology. 2019 ; Vol. 6, No. 11. pp. 2323-2327.
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