Diffuse intermediate lymphocytic lymphoma. A clinicopathologic study and comparison with small lymphocytic lymphoma and diffuse small cleaved cell lymphoma

D. A. Perry, M. A. Bast, James Olen Armitage, D. D. Weisenburger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Controversy has recently arisen as to whether diffuse intermediate lymphocytic lymphoma (ILL) should be considered a low‐grade or an intermediate‐grade non‐Hodgkin's lymphoma for clinical purposes. Therefore, the authors performed a clinicopathologic study to determine the biologic course of diffuse ILL (40 cases) and compared it with small lymphocytic lymphoma (SLL; 51 cases) and diffuse small cleaved cell lymphoma (DSCCL; 14 cases). They found that patients with diffuse ILL having pseudofollicular proliferation centers (PC) had a significantly longer median survival (84 months) than those without PC (46.5 months; P = 0.03). The median survival of patients with SLL was 72 months, whereas those with DSCCL had a median survival of only 18 months. Based on these findings, the authors conclude that diffuse ILL with PC should be included in the low‐grade category of SLL for clinical purposes, whereas diffuse ILL without PC (true diffuse ILL) should be considered an intermediate‐grade non‐Hodgkin's lymphoma. True diffuse ILL is similar to centrocytic lymphoma in the Kiel classification and should be accorded a similar status in a modified Working Formulation.

Original languageEnglish (US)
Pages (from-to)1995-2000
Number of pages6
JournalCancer
Volume66
Issue number9
DOIs
StatePublished - Nov 1 1990

Fingerprint

Mantle-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Survival
Lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Diffuse intermediate lymphocytic lymphoma. A clinicopathologic study and comparison with small lymphocytic lymphoma and diffuse small cleaved cell lymphoma. / Perry, D. A.; Bast, M. A.; Armitage, James Olen; Weisenburger, D. D.

In: Cancer, Vol. 66, No. 9, 01.11.1990, p. 1995-2000.

Research output: Contribution to journalArticle

@article{4f9e5a0d73e2402a86a90ce975342e33,
title = "Diffuse intermediate lymphocytic lymphoma. A clinicopathologic study and comparison with small lymphocytic lymphoma and diffuse small cleaved cell lymphoma",
abstract = "Controversy has recently arisen as to whether diffuse intermediate lymphocytic lymphoma (ILL) should be considered a low‐grade or an intermediate‐grade non‐Hodgkin's lymphoma for clinical purposes. Therefore, the authors performed a clinicopathologic study to determine the biologic course of diffuse ILL (40 cases) and compared it with small lymphocytic lymphoma (SLL; 51 cases) and diffuse small cleaved cell lymphoma (DSCCL; 14 cases). They found that patients with diffuse ILL having pseudofollicular proliferation centers (PC) had a significantly longer median survival (84 months) than those without PC (46.5 months; P = 0.03). The median survival of patients with SLL was 72 months, whereas those with DSCCL had a median survival of only 18 months. Based on these findings, the authors conclude that diffuse ILL with PC should be included in the low‐grade category of SLL for clinical purposes, whereas diffuse ILL without PC (true diffuse ILL) should be considered an intermediate‐grade non‐Hodgkin's lymphoma. True diffuse ILL is similar to centrocytic lymphoma in the Kiel classification and should be accorded a similar status in a modified Working Formulation.",
author = "Perry, {D. A.} and Bast, {M. A.} and Armitage, {James Olen} and Weisenburger, {D. D.}",
year = "1990",
month = "11",
day = "1",
doi = "10.1002/1097-0142(19901101)66:9<1995::AID-CNCR2820660925>3.0.CO;2-Q",
language = "English (US)",
volume = "66",
pages = "1995--2000",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Diffuse intermediate lymphocytic lymphoma. A clinicopathologic study and comparison with small lymphocytic lymphoma and diffuse small cleaved cell lymphoma

AU - Perry, D. A.

AU - Bast, M. A.

AU - Armitage, James Olen

AU - Weisenburger, D. D.

PY - 1990/11/1

Y1 - 1990/11/1

N2 - Controversy has recently arisen as to whether diffuse intermediate lymphocytic lymphoma (ILL) should be considered a low‐grade or an intermediate‐grade non‐Hodgkin's lymphoma for clinical purposes. Therefore, the authors performed a clinicopathologic study to determine the biologic course of diffuse ILL (40 cases) and compared it with small lymphocytic lymphoma (SLL; 51 cases) and diffuse small cleaved cell lymphoma (DSCCL; 14 cases). They found that patients with diffuse ILL having pseudofollicular proliferation centers (PC) had a significantly longer median survival (84 months) than those without PC (46.5 months; P = 0.03). The median survival of patients with SLL was 72 months, whereas those with DSCCL had a median survival of only 18 months. Based on these findings, the authors conclude that diffuse ILL with PC should be included in the low‐grade category of SLL for clinical purposes, whereas diffuse ILL without PC (true diffuse ILL) should be considered an intermediate‐grade non‐Hodgkin's lymphoma. True diffuse ILL is similar to centrocytic lymphoma in the Kiel classification and should be accorded a similar status in a modified Working Formulation.

AB - Controversy has recently arisen as to whether diffuse intermediate lymphocytic lymphoma (ILL) should be considered a low‐grade or an intermediate‐grade non‐Hodgkin's lymphoma for clinical purposes. Therefore, the authors performed a clinicopathologic study to determine the biologic course of diffuse ILL (40 cases) and compared it with small lymphocytic lymphoma (SLL; 51 cases) and diffuse small cleaved cell lymphoma (DSCCL; 14 cases). They found that patients with diffuse ILL having pseudofollicular proliferation centers (PC) had a significantly longer median survival (84 months) than those without PC (46.5 months; P = 0.03). The median survival of patients with SLL was 72 months, whereas those with DSCCL had a median survival of only 18 months. Based on these findings, the authors conclude that diffuse ILL with PC should be included in the low‐grade category of SLL for clinical purposes, whereas diffuse ILL without PC (true diffuse ILL) should be considered an intermediate‐grade non‐Hodgkin's lymphoma. True diffuse ILL is similar to centrocytic lymphoma in the Kiel classification and should be accorded a similar status in a modified Working Formulation.

UR - http://www.scopus.com/inward/record.url?scp=0025185175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025185175&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19901101)66:9<1995::AID-CNCR2820660925>3.0.CO;2-Q

DO - 10.1002/1097-0142(19901101)66:9<1995::AID-CNCR2820660925>3.0.CO;2-Q

M3 - Article

C2 - 2224798

AN - SCOPUS:0025185175

VL - 66

SP - 1995

EP - 2000

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -