Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal

Sung Ho Huh, Jennifer Jones, Mark E. Warchol, David M. Ornitz

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

A large proportion of age-related hearing loss is caused by loss or damage to outer hair cells in the organ of Corti. The organ of Corti is the mechanosensory transducing apparatus in the inner ear and is composed of inner hair cells, outer hair cells, and highly specialized supporting cells. The mechanisms that regulate differentiation of inner and outer hair cells are not known. Here we report that fibroblast growth factor 20 (FGF20) is required for differentiation of cells in the lateral cochlear compartment (outer hair and supporting cells) within the organ of Corti during a specific developmental time. In the absence of FGF20, mice are deaf and lateral compartment cells remain undifferentiated, postmitotic, and unresponsive to Notch-dependent lateral inhibition. These studies identify developmentally distinct medial (inner hair and supporting cells) and lateral compartments in the developing organ of Corti. The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans.

Original languageEnglish (US)
Article numbere1001231
JournalPLoS biology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2012

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Outer Auditory Hair Cells
Inner Auditory Hair Cells
Organ of Corti
fibroblast growth factors
Fibroblast Growth Factors
Cochlea
Cells
hairs
Hearing Loss
Audition
cells
hearing
Deafness
Inner Ear
Knockout Mice
Cell Differentiation
deafness
Genes
mice
cell differentiation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. / Huh, Sung Ho; Jones, Jennifer; Warchol, Mark E.; Ornitz, David M.

In: PLoS biology, Vol. 10, No. 1, e1001231, 01.01.2012.

Research output: Contribution to journalArticle

Huh, Sung Ho ; Jones, Jennifer ; Warchol, Mark E. ; Ornitz, David M. / Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. In: PLoS biology. 2012 ; Vol. 10, No. 1.
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