Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Bishuang Cai, Sai Srinivas Panapakkam Giridharan, Jing Zhang, Sugandha Saxena, Kriti Bahl, John A. Schmidt, Paul L Sorgen, Wei Guo, Naava Naslavsky, Steven H Caplan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

Original languageEnglish (US)
Pages (from-to)30172-30180
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

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Endosomes
Recycling
Electrohydrodynamics
Proteins
Cell Membrane
Cell membranes
Lipids
Assays
Protein Domains

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. / Cai, Bishuang; Giridharan, Sai Srinivas Panapakkam; Zhang, Jing; Saxena, Sugandha; Bahl, Kriti; Schmidt, John A.; Sorgen, Paul L; Guo, Wei; Naslavsky, Naava; Caplan, Steven H.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30172-30180.

Research output: Contribution to journalArticle

Cai, Bishuang ; Giridharan, Sai Srinivas Panapakkam ; Zhang, Jing ; Saxena, Sugandha ; Bahl, Kriti ; Schmidt, John A. ; Sorgen, Paul L ; Guo, Wei ; Naslavsky, Naava ; Caplan, Steven H. / Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 42. pp. 30172-30180.
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AU - Schmidt, John A.

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