Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Bishuang Cai, Sai Srinivas Panapakkam Giridharan, Jing Zhang, Sugandha Saxena, Kriti Bahl, John A. Schmidt, Paul L Sorgen, Wei Guo, Naava Naslavsky, Steven H Caplan

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Abstract

Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

Original languageEnglish (US)
Pages (from-to)30172-30180
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
Publication statusPublished - Oct 18 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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