Differential expression of the α9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells

Dwayne D. Simmons, Barbara J Morley

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The expression of the α9 nicotinic acetylcholine receptor (nAChR) subunit was investigated in perinatal and adult rat cochleae using [35S] labeled cRNA in situ hybridization techniques. In the adult, α9 expression showed both longitudinal and radial gradients. The highest expression occurs over outer hair cells (OHCs) in basal regions, and particularly, OHCs in row 1. In contrast, expression over IHCs is lowest in basal regions and highest in apical regions. During embryonic and postnatal ages, the pattern of α9 expression differs. Expression of α9 was nearly equivalent over IHCs and OHCs. Additionally, the greater epithelial ridge, which is adjacent to IHCs before birth, shows a high level of α9 expression. These data are consistent with current models of efferent synaptogenesis and suggest that the expression of the α9 nAChR may be influenced by the arrival of efferent axons.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalMolecular Brain Research
Volume56
Issue number1-2
DOIs
StatePublished - May 1 1998

Fingerprint

Outer Auditory Hair Cells
Auditory Hair Cells
Nicotinic Receptors
Complementary RNA
Cochlea
In Situ Hybridization
Axons
Parturition

Keywords

  • Efferent
  • Hybridization, in situ
  • Olivocochlear
  • Organ of Corti
  • Synaptogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Differential expression of the α9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells. / Simmons, Dwayne D.; Morley, Barbara J.

In: Molecular Brain Research, Vol. 56, No. 1-2, 01.05.1998, p. 287-292.

Research output: Contribution to journalArticle

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