Differential expression of CD24-related epitopes in mycosis fungoides/Sézary syndrome

A potential marker for circulating sézary cells

Samuel Jay Pirruccello, Molly S. Lang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In the hematopoietic system, the B-cell associated antigen CD24 is expressed at high density on B cells, B-cell precursors, and B-cell malignancies as well as at low density on peripheral blood polymorphonuclear leukocytes. The 42-Kd sialoglycoprotein has not been previously demonstrated to be expressed on T cells, thymocytes. or T-cell malignancies. We identified three patients with mycosis fungoides/Sézary syndrome that showed low density expression of the CD24-related epitope recognized by antibody BA-1 on circulating T cells. All three patients had Sézary cells by morphologic assessment and clonal T-cell populations in the peripheral blood by gene rearrangement studies. In two of these patients, indirect immunofluorescence with a panel of six anti-CD24 monoclonal antibodies demonstrated reactivity for two of six antibodies in one case and only one of six antibodies in the other. The biologic significance of CD24-related epitope expression on circulating T cells in mycosis fungoides/Sézary syndrome is unclear. However, these findings suggest that differential, low density expression of CD24-related epitopes (BA-1+. OKB2-) may be a useful phenotypic marker for identifying circulating Sézary cells.

Original languageEnglish (US)
Pages (from-to)2343-2347
Number of pages5
JournalBlood
Volume76
Issue number11
StatePublished - Dec 1 1990

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Mycosis Fungoides
T-cells
Epitopes
T-Lymphocytes
Cells
B-Lymphocytes
CD24 Antigens
Antibodies
Blood
Sialoglycoproteins
Hematopoietic System
B-Lymphoid Precursor Cells
Gene Rearrangement
Thymocytes
Indirect Fluorescent Antibody Technique
Neoplasms
Neutrophils
Genes
Monoclonal Antibodies
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Differential expression of CD24-related epitopes in mycosis fungoides/Sézary syndrome : A potential marker for circulating sézary cells. / Pirruccello, Samuel Jay; Lang, Molly S.

In: Blood, Vol. 76, No. 11, 01.12.1990, p. 2343-2347.

Research output: Contribution to journalArticle

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abstract = "In the hematopoietic system, the B-cell associated antigen CD24 is expressed at high density on B cells, B-cell precursors, and B-cell malignancies as well as at low density on peripheral blood polymorphonuclear leukocytes. The 42-Kd sialoglycoprotein has not been previously demonstrated to be expressed on T cells, thymocytes. or T-cell malignancies. We identified three patients with mycosis fungoides/S{\'e}zary syndrome that showed low density expression of the CD24-related epitope recognized by antibody BA-1 on circulating T cells. All three patients had S{\'e}zary cells by morphologic assessment and clonal T-cell populations in the peripheral blood by gene rearrangement studies. In two of these patients, indirect immunofluorescence with a panel of six anti-CD24 monoclonal antibodies demonstrated reactivity for two of six antibodies in one case and only one of six antibodies in the other. The biologic significance of CD24-related epitope expression on circulating T cells in mycosis fungoides/S{\'e}zary syndrome is unclear. However, these findings suggest that differential, low density expression of CD24-related epitopes (BA-1+. OKB2-) may be a useful phenotypic marker for identifying circulating S{\'e}zary cells.",
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