Differential effects of cardiac sympathetic afferent stimulation on neurons in the nucleus tractus solitarius

Wei Zhong Wang, Lie Gao, Yan Xia Pan, Irving H Zucker, Wei Wang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Activation of the cardiac "sympathetic afferent" reflex (CSAR) has been reported to depress the arterial baroreflex and enhance the arterial chemoreflex via a central mechanism. In the present study, we used single-unit extracellular recording techniques to examine the effects of stimulation of cardiac sympathetic afferents on baro- or chemosensitive neurons in the nucleus tractus solitarius (NTS) in anesthetized rats. Of 54 barosensitive NTS neurons tested for their response to epicardial application of capsaicin (0.4 μg), 38 were significantly (P < 0.01) inhibited by 38% while 16 did not respond. Of 42 NTS chemosensitive neurons tested for their response to capsaicin, 33 were significantly (P < 0.01) excited by 47% while 9 did not respond. In addition, of 12 both barosensitive and chemosensitive NTS neurons tested for capsaicin, 2 were excited, 7 were inhibited, and 3 did not respond. In conclusion, this study indicates that CSAR activation inhibited NTS barosensitive neurons and excited NTS chemosensitive neurons, suggesting that the NTS plays an important role in processing the interactions between these cardiovascular reflexes.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalNeuroscience Letters
Volume409
Issue number2
DOIs
StatePublished - Dec 1 2006

Fingerprint

Solitary Nucleus
Neurons
Capsaicin
Reflex
Baroreflex

Keywords

  • Baro-/chemosensitive neuron
  • Capsaicin
  • Cardiovascular reflexes
  • Extracellular recording
  • Sympathetic activity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential effects of cardiac sympathetic afferent stimulation on neurons in the nucleus tractus solitarius. / Wang, Wei Zhong; Gao, Lie; Pan, Yan Xia; Zucker, Irving H; Wang, Wei.

In: Neuroscience Letters, Vol. 409, No. 2, 01.12.2006, p. 146-150.

Research output: Contribution to journalArticle

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