Differential displacement of classical cadherins by VE-cadherin

Meena Jaggi, Margaret J. Wheelock, Keith R Johnson

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE-and N-cadherin; VE-cadherin is present in junctions while N-cadherin is diffusely expressed over the surface of the cell. The present study was designed first to determine if the ability of VE-cadherin to displace N-cadherin from junctions was endothelial-cell specific, and second to determine if VE-cadherin could displace other classical cadherins from cell junctions. Our data suggest that VE-cadherin specifically influences the cellular localization of N-cadherin, independent of cell type, and does not effect the localization of other classical cadherins.

Original languageEnglish (US)
Pages (from-to)103-115
Number of pages13
JournalCell Communication and Adhesion
Volume9
Issue number2
Publication statusPublished - Mar 1 2002

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Keywords

  • E-cadherin
  • N-cadherin
  • VE-cadherin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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