Differences in Phosphate Metabolite Levels in Drug-sensitive and -resistant Human Breast Cancer Cell Lines Determined by 31p Magnetic Resonance Spectroscopy

J. S. Cohen, R. C. Lyon, C. Chen, P. J. Faustino, M. Shoemaker, E. Rubalcaba, K. H. Cowan

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

31P magnetic resonance spectra of perfused human breast cancer cells with the phenotype of pleiotropic drug resistance exhibit striking differences in the levels of phosphate metabolites from the wild-type, drug-sensitive parent cell line. Resistant cells demonstrated elevated levels of phosphocreatine and depressed levels of phosphomonoesters, phosphodiesters, and diphosphodiesters. These differences may reflect significant alterations in the control of bioenergetic metabolism between drug-resistant and -sensitive cells. copyright.

Original languageEnglish (US)
Pages (from-to)4087-4090
Number of pages4
JournalCancer Research
Volume46
Issue number8
StatePublished - Aug 1 1986

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Magnetic Resonance Spectroscopy
Phosphates
Breast Neoplasms
Cell Line
Pharmaceutical Preparations
Phosphocreatine
Drug Resistance
Energy Metabolism
Phenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Differences in Phosphate Metabolite Levels in Drug-sensitive and -resistant Human Breast Cancer Cell Lines Determined by 31p Magnetic Resonance Spectroscopy. / Cohen, J. S.; Lyon, R. C.; Chen, C.; Faustino, P. J.; Shoemaker, M.; Rubalcaba, E.; Cowan, K. H.

In: Cancer Research, Vol. 46, No. 8, 01.08.1986, p. 4087-4090.

Research output: Contribution to journalArticle

Cohen, J. S. ; Lyon, R. C. ; Chen, C. ; Faustino, P. J. ; Shoemaker, M. ; Rubalcaba, E. ; Cowan, K. H. / Differences in Phosphate Metabolite Levels in Drug-sensitive and -resistant Human Breast Cancer Cell Lines Determined by 31p Magnetic Resonance Spectroscopy. In: Cancer Research. 1986 ; Vol. 46, No. 8. pp. 4087-4090.
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