Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults

Shan Fan, Tao Guo, Baojiang Chen, Junqun Xiong, Shane Havens, Vikas Gulati, Carol B. Toris

Research output: Contribution to journalArticle

Abstract

Background Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups. Methods Data from two independent studies with identical designs were compared. Cohorts included young adults (20-30 years old, 32 Chinese and 39 Caucasians) and older adults (>50 years old, 37 Chinese and 46 Caucasians). Parameters of AHD and ocular biometrics were evaluated. Group comparisons were made by generalised estimating equation methods. Results Differences in young adult Caucasians compared with similarly aged Chinese were thinner central cornea (-29.27 μm, p<0.001), lower intraocular pressure (IOP) (-2.33 mm Hg, p<0.001), larger anterior chamber volume (ACV) (28.78 μL, p<0.001) and faster uveoscleral outflow rate (Fu) (0.82 μL/min, p<0.001). Differences in older adult Caucasians compared with similarly aged Chinese were slower aqueous flow rate (Fa) (-0.28 μL/min, p=0.042), lower IOP (-1.97 mm Hg, p<0.001) and larger ACV (33.15 μL, p<0.001). Considering all subjects together by race, Caucasian subjects had slower Fa (-0.22 μL/min, p=0.035), thinner corneas (-0.52 μm, p=0.003), lower IOP (-2.11 mm Hg, p<0.001), higher ACV (30.39 μL, p<0.001) and faster Fu (0.63 μL/min, p<0.001). Conclusion Differences in AHD and biometrics between Caucasian and Chinese adults include larger ACVs which may contribute to the wider angles reported in Caucasians, and slower Fa rates coupled with faster Fu rates which may contribute to their lower IOP and lower overall risk of glaucoma.

Original languageEnglish (US)
Pages (from-to)1845-1849
Number of pages5
JournalBritish Journal of Ophthalmology
Volume103
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Aqueous Humor
Intraocular Pressure
Anterior Chamber
Glaucoma
Cornea
Young Adult
Ethnic Groups
Age Groups

Keywords

  • anterior chamber
  • ciliary body
  • glaucoma
  • intraocular pressure
  • physiology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults. / Fan, Shan; Guo, Tao; Chen, Baojiang; Xiong, Junqun; Havens, Shane; Gulati, Vikas; Toris, Carol B.

In: British Journal of Ophthalmology, Vol. 103, No. 12, 01.12.2019, p. 1845-1849.

Research output: Contribution to journalArticle

@article{021e931744db417c863dc3693331bf67,
title = "Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults",
abstract = "Background Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups. Methods Data from two independent studies with identical designs were compared. Cohorts included young adults (20-30 years old, 32 Chinese and 39 Caucasians) and older adults (>50 years old, 37 Chinese and 46 Caucasians). Parameters of AHD and ocular biometrics were evaluated. Group comparisons were made by generalised estimating equation methods. Results Differences in young adult Caucasians compared with similarly aged Chinese were thinner central cornea (-29.27 μm, p<0.001), lower intraocular pressure (IOP) (-2.33 mm Hg, p<0.001), larger anterior chamber volume (ACV) (28.78 μL, p<0.001) and faster uveoscleral outflow rate (Fu) (0.82 μL/min, p<0.001). Differences in older adult Caucasians compared with similarly aged Chinese were slower aqueous flow rate (Fa) (-0.28 μL/min, p=0.042), lower IOP (-1.97 mm Hg, p<0.001) and larger ACV (33.15 μL, p<0.001). Considering all subjects together by race, Caucasian subjects had slower Fa (-0.22 μL/min, p=0.035), thinner corneas (-0.52 μm, p=0.003), lower IOP (-2.11 mm Hg, p<0.001), higher ACV (30.39 μL, p<0.001) and faster Fu (0.63 μL/min, p<0.001). Conclusion Differences in AHD and biometrics between Caucasian and Chinese adults include larger ACVs which may contribute to the wider angles reported in Caucasians, and slower Fa rates coupled with faster Fu rates which may contribute to their lower IOP and lower overall risk of glaucoma.",
keywords = "anterior chamber, ciliary body, glaucoma, intraocular pressure, physiology",
author = "Shan Fan and Tao Guo and Baojiang Chen and Junqun Xiong and Shane Havens and Vikas Gulati and Toris, {Carol B.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1136/bjophthalmol-2018-313132",
language = "English (US)",
volume = "103",
pages = "1845--1849",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "12",

}

TY - JOUR

T1 - Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults

AU - Fan, Shan

AU - Guo, Tao

AU - Chen, Baojiang

AU - Xiong, Junqun

AU - Havens, Shane

AU - Gulati, Vikas

AU - Toris, Carol B.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups. Methods Data from two independent studies with identical designs were compared. Cohorts included young adults (20-30 years old, 32 Chinese and 39 Caucasians) and older adults (>50 years old, 37 Chinese and 46 Caucasians). Parameters of AHD and ocular biometrics were evaluated. Group comparisons were made by generalised estimating equation methods. Results Differences in young adult Caucasians compared with similarly aged Chinese were thinner central cornea (-29.27 μm, p<0.001), lower intraocular pressure (IOP) (-2.33 mm Hg, p<0.001), larger anterior chamber volume (ACV) (28.78 μL, p<0.001) and faster uveoscleral outflow rate (Fu) (0.82 μL/min, p<0.001). Differences in older adult Caucasians compared with similarly aged Chinese were slower aqueous flow rate (Fa) (-0.28 μL/min, p=0.042), lower IOP (-1.97 mm Hg, p<0.001) and larger ACV (33.15 μL, p<0.001). Considering all subjects together by race, Caucasian subjects had slower Fa (-0.22 μL/min, p=0.035), thinner corneas (-0.52 μm, p=0.003), lower IOP (-2.11 mm Hg, p<0.001), higher ACV (30.39 μL, p<0.001) and faster Fu (0.63 μL/min, p<0.001). Conclusion Differences in AHD and biometrics between Caucasian and Chinese adults include larger ACVs which may contribute to the wider angles reported in Caucasians, and slower Fa rates coupled with faster Fu rates which may contribute to their lower IOP and lower overall risk of glaucoma.

AB - Background Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups. Methods Data from two independent studies with identical designs were compared. Cohorts included young adults (20-30 years old, 32 Chinese and 39 Caucasians) and older adults (>50 years old, 37 Chinese and 46 Caucasians). Parameters of AHD and ocular biometrics were evaluated. Group comparisons were made by generalised estimating equation methods. Results Differences in young adult Caucasians compared with similarly aged Chinese were thinner central cornea (-29.27 μm, p<0.001), lower intraocular pressure (IOP) (-2.33 mm Hg, p<0.001), larger anterior chamber volume (ACV) (28.78 μL, p<0.001) and faster uveoscleral outflow rate (Fu) (0.82 μL/min, p<0.001). Differences in older adult Caucasians compared with similarly aged Chinese were slower aqueous flow rate (Fa) (-0.28 μL/min, p=0.042), lower IOP (-1.97 mm Hg, p<0.001) and larger ACV (33.15 μL, p<0.001). Considering all subjects together by race, Caucasian subjects had slower Fa (-0.22 μL/min, p=0.035), thinner corneas (-0.52 μm, p=0.003), lower IOP (-2.11 mm Hg, p<0.001), higher ACV (30.39 μL, p<0.001) and faster Fu (0.63 μL/min, p<0.001). Conclusion Differences in AHD and biometrics between Caucasian and Chinese adults include larger ACVs which may contribute to the wider angles reported in Caucasians, and slower Fa rates coupled with faster Fu rates which may contribute to their lower IOP and lower overall risk of glaucoma.

KW - anterior chamber

KW - ciliary body

KW - glaucoma

KW - intraocular pressure

KW - physiology

UR - http://www.scopus.com/inward/record.url?scp=85063270602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063270602&partnerID=8YFLogxK

U2 - 10.1136/bjophthalmol-2018-313132

DO - 10.1136/bjophthalmol-2018-313132

M3 - Article

C2 - 30894342

AN - SCOPUS:85063270602

VL - 103

SP - 1845

EP - 1849

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 12

ER -