28 Citations (Scopus)

Abstract

Cytochrome P-450 in rat liver nuclei was distinguishable from that in the corresponding liver microsomes. Characterization racterization was carried out using carbon monoxide and ethyl isocyanide binding difference spectra. Nuclear cytochrome P-450 in 3-methylcholanthrene-induced animals had different spectral properties from the nuclear cytochrome P-450 in uninduced and phenobarbital-induced animals. These spectral data demonstrate that hepatic nuclear cytochrome P-450 differs from the microsomal species.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalMolecular pharmacology
Volume14
Issue number1
StatePublished - Jan 1 1978

Fingerprint

Cytochrome P-450 Enzyme System
Liver
Methylcholanthrene
Liver Microsomes
Carbon Monoxide
Phenobarbital

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Differences between nuclear and microsomal cytochrome P-450 in uninduced and induced rat liver. / Rogan, Eleanor G; Cavalieri, Ercole.

In: Molecular pharmacology, Vol. 14, No. 1, 01.01.1978, p. 215-219.

Research output: Contribution to journalArticle

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