Cytochrome P-450 in rat liver nuclei was distinguishable from that in the corresponding liver microsomes. Characterization racterization was carried out using carbon monoxide and ethyl isocyanide binding difference spectra. Nuclear cytochrome P-450 in 3-methylcholanthrene-induced animals had different spectral properties from the nuclear cytochrome P-450 in uninduced and phenobarbital-induced animals. These spectral data demonstrate that hepatic nuclear cytochrome P-450 differs from the microsomal species.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalMolecular pharmacology
Issue number1
StatePublished - Jan 1 1978


ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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