Dietary selenium affects host selenoproteome expression by influencing the gut microbiota

Marina V. Kasaikina, Marina A. Kravtsova, Byung Cheon Lee, Javier Seravalli, Daniel A. Peterson, Jens Walter, Ryan Legge, Andrew K Benson, Dolph L. Hatfield, Vadim N. Gladyshev

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Colonization of the gastrointestinal tract and composition of the microbiota may be influenced by components of the diet, including trace elements. To understand how selenium regulates the intestinal microflora, we used high-throughput sequencing to examine the composition of gut microbiota of mice maintained on selenium-deficient, selenium-sufficient, and selenium-enriched diets. The microbiota diversity increased as a result of selenium in the diet. Specific phylotypes showed differential effects of selenium, even within a genus, implying that selenium had unique effects across microbial taxa. Conventionalized germ-free mice subjected to selenium diets gave similar results and showed an increased diversity of the bacterial population in animals fed with higher levels of selenium. Germ-free mice fed selenium diets modified their selenoproteome expression similar to control mice but showed higher levels and activity of glutathione peroxidase 1 and methionine-R- sulfoxide reductase 1 in the liver, suggesting partial sequestration of selenium by the gut microorganisms, limiting its availability for the host. These changes in the selenium status were independent of the levels of other trace elements. The data show that dietary selenium affects both composition of the intestinal microflora and colonization of the gastrointestinal tract, which, in turn, influence the host selenium status and selenoproteome expression.

Original languageEnglish (US)
Pages (from-to)2492-2499
Number of pages8
JournalFASEB Journal
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Selenium
Nutrition
Diet
Microbiota
Trace Elements
Gastrointestinal Microbiome
Gastrointestinal Tract
Methionine Sulfoxide Reductases
Chemical analysis
Microorganisms
Liver
Animals
Throughput
Availability

Keywords

  • Germ-free mice
  • High-throughput sequencing
  • Selenoproteins

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Kasaikina, M. V., Kravtsova, M. A., Lee, B. C., Seravalli, J., Peterson, D. A., Walter, J., ... Gladyshev, V. N. (2011). Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB Journal, 25(7), 2492-2499. https://doi.org/10.1096/fj.11-181990

Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. / Kasaikina, Marina V.; Kravtsova, Marina A.; Lee, Byung Cheon; Seravalli, Javier; Peterson, Daniel A.; Walter, Jens; Legge, Ryan; Benson, Andrew K; Hatfield, Dolph L.; Gladyshev, Vadim N.

In: FASEB Journal, Vol. 25, No. 7, 01.07.2011, p. 2492-2499.

Research output: Contribution to journalArticle

Kasaikina, MV, Kravtsova, MA, Lee, BC, Seravalli, J, Peterson, DA, Walter, J, Legge, R, Benson, AK, Hatfield, DL & Gladyshev, VN 2011, 'Dietary selenium affects host selenoproteome expression by influencing the gut microbiota', FASEB Journal, vol. 25, no. 7, pp. 2492-2499. https://doi.org/10.1096/fj.11-181990
Kasaikina, Marina V. ; Kravtsova, Marina A. ; Lee, Byung Cheon ; Seravalli, Javier ; Peterson, Daniel A. ; Walter, Jens ; Legge, Ryan ; Benson, Andrew K ; Hatfield, Dolph L. ; Gladyshev, Vadim N. / Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. In: FASEB Journal. 2011 ; Vol. 25, No. 7. pp. 2492-2499.
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