Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma

Briseis Aschebrook-Kilfoy, Mary H. Ward, Bhavana J Dave, Sonali M. Smith, Dennis D. Weisenburger, Brian C H Chiu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although established risk factors such as immunodeficiency and viral infections may be responsible for a portion of cases of non-Hodgkin lymphoma (NHL), the vast majority of cases of NHL remain unexplained. The role of dietary nitrate and nitrite in NHL risk is of interest since they are precursors of N-nitroso compounds, and nitrosoureas have been shown to induce B-and T-cell lymphomas in animal studies. However, few studies have evaluated the potential association between consumption of nitrate and nitrite and NHL by subtype or chromosomal translocation status, and the results of these studies have been inconsistent. We estimated the dietary intake of nitrate and nitrite using a food frequency questionnaire in a population-based, casecontrol study of 348 cases and 470 controls conducted in Nebraska in 19992002. A non-significant excess risk of NHL was found among women who reported an intake of nitrite in the highest quartile compared to the lowest quartile (odds ratio [OR] = 1.6; 95% confidence interval [CI]: 0.82.9), particularly nitrite from animal sources (OR = 1.9; 95% CI: 1.03.4). No significant associations were observed for nitrate or nitrite by NHL subtype. Although there were some increases in risk that support the N-nitroso hypothesis, they were not significant and do not confer strong evidence of an association.

Original languageEnglish (US)
Pages (from-to)945-950
Number of pages6
JournalLeukemia and Lymphoma
Volume54
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Nitrites
Nitrates
Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
Nitroso Compounds
Genetic Translocation
T-Cell Lymphoma
B-Cell Lymphoma
Virus Diseases
Food
Population

Keywords

  • Diet
  • Nitrate
  • Nitrite
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Aschebrook-Kilfoy, B., Ward, M. H., Dave, B. J., Smith, S. M., Weisenburger, D. D., & Chiu, B. C. H. (2013). Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma. Leukemia and Lymphoma, 54(5), 945-950. https://doi.org/10.3109/10428194.2012.734613

Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma. / Aschebrook-Kilfoy, Briseis; Ward, Mary H.; Dave, Bhavana J; Smith, Sonali M.; Weisenburger, Dennis D.; Chiu, Brian C H.

In: Leukemia and Lymphoma, Vol. 54, No. 5, 01.05.2013, p. 945-950.

Research output: Contribution to journalArticle

Aschebrook-Kilfoy, B, Ward, MH, Dave, BJ, Smith, SM, Weisenburger, DD & Chiu, BCH 2013, 'Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma', Leukemia and Lymphoma, vol. 54, no. 5, pp. 945-950. https://doi.org/10.3109/10428194.2012.734613
Aschebrook-Kilfoy B, Ward MH, Dave BJ, Smith SM, Weisenburger DD, Chiu BCH. Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma. Leukemia and Lymphoma. 2013 May 1;54(5):945-950. https://doi.org/10.3109/10428194.2012.734613
Aschebrook-Kilfoy, Briseis ; Ward, Mary H. ; Dave, Bhavana J ; Smith, Sonali M. ; Weisenburger, Dennis D. ; Chiu, Brian C H. / Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma. In: Leukemia and Lymphoma. 2013 ; Vol. 54, No. 5. pp. 945-950.
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