Dietary factors promoting brown and beige fat development and thermogenesis

Meshail Okla, Jiyoung Kim, Karsten Koehler, Soonkyu Chungn

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes. Despite advances in knowledge regarding the developmental lineage and transcriptional regulators of brown and beige adipocytes, our current understanding of environmental modifiers of BAT thermogenesis, such as diet, is limited. In this review, we consolidated the latest research on dietary molecules that may serve to promote BAT thermogenesis. Here, we summarized the thermogenic function of selected phytochemicals (e.g., capsaicin, resveratrol, curcumin, green tea, and berberine), dietary fatty acids (e.g., fish oil and conjugated linoleic acids), and all-trans retinoic acid, a vitamin A metabolite. We also delineated the proposed mechanisms whereby these dietary molecules promote BAT activity and/or browning of white adipose tissue. Characterizing thermogenic dietary factors may offer novel insight into revising nutritional intervention strategies aimed at obesity and diabetes prevention and management.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
JournalAdvances in Nutrition
Volume8
Issue number3
DOIs
StatePublished - May 1 2017

Fingerprint

Brown Adipose Tissue
brown adipose tissue
Thermogenesis
heat production
lipids
diet
diabetes
obesity
Obesity
Brown Adipocytes
Cell Respiration
Berberine
berberine
Conjugated Linoleic Acids
White Adipose Tissue
white adipose tissue
capsaicin
Curcumin
modifiers (genes)
curcumin

Keywords

  • Beige adipocytes
  • Brown adipocyte
  • Dietary molecule
  • Thermogenesis
  • UCP1
  • WAT browning

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Dietary factors promoting brown and beige fat development and thermogenesis. / Okla, Meshail; Kim, Jiyoung; Koehler, Karsten; Chungn, Soonkyu.

In: Advances in Nutrition, Vol. 8, No. 3, 01.05.2017, p. 473-483.

Research output: Contribution to journalReview article

Okla, Meshail ; Kim, Jiyoung ; Koehler, Karsten ; Chungn, Soonkyu. / Dietary factors promoting brown and beige fat development and thermogenesis. In: Advances in Nutrition. 2017 ; Vol. 8, No. 3. pp. 473-483.
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