Dietary carbohydrate (cho) type and amount interact to alter vldl and ldl metabolism in guinea pigs

Ghada Soliman, M. Vergara-Jimenez, K. A. Conde, M. L. Femandez

Research output: Contribution to journalArticle

Abstract

Guinea pigs were fed two different fat:CHO ratios: 2.5:58% (w/w) or 25:29% (w/w) with either sucrose or starch as the sole CHO source to determine the effects of CHO type and amount on specific sites of plasma VLDL and LDL metabolism Intake of high fat diets resulted in higher plasma LDL cholesterol levels (P < 0.01) while simple CHO increased plasma triacylglycerol (TAG) concentrations (P < 0.05). Animals fed starch diets exhibited a nascent VLDL containing less TAG/apo B and they also had faster VLDL apo B clearance than animals fed sucrose diets. In addition, VLDL removal from plasma with complex CHO:high fat intake was associated with less conversion of VLDL to LDL and decreased plasma cholesterol levels compared to the high fat: sucrose group Low fat intake compared to high fat intake resulted in 60% more rapid plasma LDL apo B fractional catabolic rates These results demonstrate that while low fat diets decrease plasma LDL cholesterol concentrations by increasing plasma LDL turnover rates, complex CHO reduce plasma TAG by affecting nascent VLDL composition and increasing VLDL apo B catabolism. [Studies supported by the American Heart Association, Arizona Affiliate],.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

Fingerprint

Dietary Carbohydrates
dietary carbohydrate
fat intake
Metabolism
guinea pigs
Guinea Pigs
triacylglycerols
sucrose
low density lipoprotein cholesterol
Plasmas
metabolism
Fats
Apolipoproteins B
starch
Nutrition
low fat diet
high fat diet
lipids
diet
Sucrose

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Soliman, G., Vergara-Jimenez, M., Conde, K. A., & Femandez, M. L. (1996). Dietary carbohydrate (cho) type and amount interact to alter vldl and ldl metabolism in guinea pigs. FASEB Journal, 10(3).

Dietary carbohydrate (cho) type and amount interact to alter vldl and ldl metabolism in guinea pigs. / Soliman, Ghada; Vergara-Jimenez, M.; Conde, K. A.; Femandez, M. L.

In: FASEB Journal, Vol. 10, No. 3, 01.12.1996.

Research output: Contribution to journalArticle

Soliman, G, Vergara-Jimenez, M, Conde, KA & Femandez, ML 1996, 'Dietary carbohydrate (cho) type and amount interact to alter vldl and ldl metabolism in guinea pigs', FASEB Journal, vol. 10, no. 3.
Soliman, Ghada ; Vergara-Jimenez, M. ; Conde, K. A. ; Femandez, M. L. / Dietary carbohydrate (cho) type and amount interact to alter vldl and ldl metabolism in guinea pigs. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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