Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues

Synthesis and preliminary evaluation

Janina Baranowska-Kortylewicz, Edward J. Pavlik, Walter T. Smith, Robert C. Flanigan, J. R. Van Nagell, Dawn Ross, Daniel E. Kenady

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalInorganica Chimica Acta
Volume108
Issue number2
DOIs
StatePublished - Jan 1 1985

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Platinum
platinum
analogs
evaluation
synthesis
Kidney
kidneys
viability
toxicity
Cisplatin
mice
Toxicity
hydrolysis
Tumors
Hydrolysis
Cell Survival
tumors
Cells
Cell Proliferation
Temperature

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues : Synthesis and preliminary evaluation. / Baranowska-Kortylewicz, Janina; Pavlik, Edward J.; Smith, Walter T.; Flanigan, Robert C.; Van Nagell, J. R.; Ross, Dawn; Kenady, Daniel E.

In: Inorganica Chimica Acta, Vol. 108, No. 2, 01.01.1985, p. 91-98.

Research output: Contribution to journalArticle

Baranowska-Kortylewicz, Janina ; Pavlik, Edward J. ; Smith, Walter T. ; Flanigan, Robert C. ; Van Nagell, J. R. ; Ross, Dawn ; Kenady, Daniel E. / Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues : Synthesis and preliminary evaluation. In: Inorganica Chimica Acta. 1985 ; Vol. 108, No. 2. pp. 91-98.
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AU - Smith, Walter T.

AU - Flanigan, Robert C.

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AU - Ross, Dawn

AU - Kenady, Daniel E.

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