Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients

Jean François Timsit, Romain Sonneville, Andre C. Kalil, Matteo Bassetti, Ricard Ferrer, Samir Jaber, Fanny Lanternier, Charles Edouard Luyt, Flavia Machado, Malgorzata Mikulska, Laurent Papazian, Fréderic Pène, Garyphalia Poulakou, Claudio Viscoli, Michel Wolff, Lara Zafrani, Christian Van Delden

Research output: Contribution to journalReview article

Abstract

Purpose: Prognosis of solid organ transplant (SOT) recipients has improved, mainly because of better prevention of rejection by immunosuppressive therapies. However, SOT recipients are highly susceptible to conventional and opportunistic infections, which represent a major cause of morbidity, graft dysfunction and mortality. Methods: Narrative review. Results: We cover the current epidemiology and main aspects of infections in SOT recipients including risk factors such as postoperative risks and specific risks for different transplant recipients, key points on anti-infective prophylaxis as well as diagnostic and therapeutic approaches. We provide an up-to-date guide for management of the main syndromes that can be encountered in SOT recipients including acute respiratory failure, sepsis or septic shock, and central nervous system infections as well as bacterial infections with multidrug-resistant strains, invasive fungal diseases, viral infections and less common pathogens that may impact this patient population. Conclusion: We provide state-of the art review of available knowledge of critically ill SOT patients with infections.

Original languageEnglish (US)
Pages (from-to)573-591
Number of pages19
JournalIntensive Care Medicine
Volume45
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Communicable Diseases
Transplants
Therapeutics
Central Nervous System Infections
Mycoses
Opportunistic Infections
Virus Diseases
Immunosuppressive Agents
Septic Shock
Infection
Bacterial Infections
Critical Illness
Respiratory Insufficiency
Transplant Recipients
Sepsis
Epidemiology
Morbidity
Mortality
Population

Keywords

  • Immunocompromized
  • Outcome
  • Sepsis
  • Septic shock
  • Solid organ recipient

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients. / Timsit, Jean François; Sonneville, Romain; Kalil, Andre C.; Bassetti, Matteo; Ferrer, Ricard; Jaber, Samir; Lanternier, Fanny; Luyt, Charles Edouard; Machado, Flavia; Mikulska, Malgorzata; Papazian, Laurent; Pène, Fréderic; Poulakou, Garyphalia; Viscoli, Claudio; Wolff, Michel; Zafrani, Lara; Van Delden, Christian.

In: Intensive Care Medicine, Vol. 45, No. 5, 01.05.2019, p. 573-591.

Research output: Contribution to journalReview article

Timsit, JF, Sonneville, R, Kalil, AC, Bassetti, M, Ferrer, R, Jaber, S, Lanternier, F, Luyt, CE, Machado, F, Mikulska, M, Papazian, L, Pène, F, Poulakou, G, Viscoli, C, Wolff, M, Zafrani, L & Van Delden, C 2019, 'Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients', Intensive Care Medicine, vol. 45, no. 5, pp. 573-591. https://doi.org/10.1007/s00134-019-05597-y
Timsit, Jean François ; Sonneville, Romain ; Kalil, Andre C. ; Bassetti, Matteo ; Ferrer, Ricard ; Jaber, Samir ; Lanternier, Fanny ; Luyt, Charles Edouard ; Machado, Flavia ; Mikulska, Malgorzata ; Papazian, Laurent ; Pène, Fréderic ; Poulakou, Garyphalia ; Viscoli, Claudio ; Wolff, Michel ; Zafrani, Lara ; Van Delden, Christian. / Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients. In: Intensive Care Medicine. 2019 ; Vol. 45, No. 5. pp. 573-591.
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AU - Jaber, Samir

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AU - Pène, Fréderic

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