Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida: A case study

D. E. Hostetler, D. J. Sprecher, B. Yamini, N. K. Ames

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resembled known equine granulosa cell tumor (GCT) images. Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariectomy was performed. The presurgical serum concentration of testosterone was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentration returned to baseline, and the heifer was diagnosed pregnant following AI. A low grade, malignant GCT was the final histopathologically diagnosis. Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. An ultrasound image, similar to the one shown, may be characteristic of GCT in the bovine.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalTheriogenology
Volume48
Issue number1
DOIs
StatePublished - Jul 1 1997

Fingerprint

Granulosa Cell Tumor
granulosa cells
Holstein
case studies
neoplasms
testosterone
Testosterone
masculinization
Virilism
ovariectomy
Palpation
Estrus
Ovariectomy
steroid hormones
Serum
ultrasonography
Horses
estrus
heifers
Ovary

Keywords

  • Bovine
  • Granulosa cell tumor
  • Malignant
  • Nulligravida
  • Testosterone

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

Cite this

Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida : A case study. / Hostetler, D. E.; Sprecher, D. J.; Yamini, B.; Ames, N. K.

In: Theriogenology, Vol. 48, No. 1, 01.07.1997, p. 11-17.

Research output: Contribution to journalArticle

Hostetler, D. E. ; Sprecher, D. J. ; Yamini, B. ; Ames, N. K. / Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida : A case study. In: Theriogenology. 1997 ; Vol. 48, No. 1. pp. 11-17.
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