Diacylglycerol kinases in membrane trafficking

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity. These differences allow regulation of cellular responses by fine-tuning the delicate balance of cellular DAG and PA. DGK isoforms are best characterized as mediators of signal transduction and immune function. However, since recent studies reveal that DAG and PA are also involved in the regulation of endocytic trafficking, it is therefore anticipated that DGKs also plays an important role in membrane trafficking. In this review, we summarize the literature discussing the role of DGK isoforms at different stages of endocytic trafficking, including endocytosis, exocytosis, endocytic recycling, and transport from/to the Golgi apparatus. Overall, these studies contribute to our understanding of the involvement of PA and DAG in endocytic trafficking, an area of research that is drawing increasing attention in recent years.

Original languageEnglish (US)
JournalCellular Logistics
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2015

Fingerprint

Diacylglycerol Kinase
Phosphatidic Acids
Diglycerides
Membranes
Protein Isoforms
Signal transduction
Organ Specificity
Phosphorylation
Exocytosis
Golgi Apparatus
Tissue Distribution
Substrate Specificity
Endocytosis
Recycling
Signal Transduction
Phosphotransferases
Tuning
Tissue
Substrates
Research

Keywords

  • Diacylglycerol
  • Diacylglycerol kinase
  • Endocytic recycling
  • Golgi
  • Membrane trafficking
  • MICAL-L1
  • Phosphatidic acid

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Medicine

Cite this

Diacylglycerol kinases in membrane trafficking. / Xie, Shuwei; Naslavsky, Naava; Caplan, Steven H.

In: Cellular Logistics, Vol. 5, No. 2, 01.01.2015.

Research output: Contribution to journalReview article

@article{cfebc6b41d654eb2854f91c4b92e67d8,
title = "Diacylglycerol kinases in membrane trafficking",
abstract = "Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity. These differences allow regulation of cellular responses by fine-tuning the delicate balance of cellular DAG and PA. DGK isoforms are best characterized as mediators of signal transduction and immune function. However, since recent studies reveal that DAG and PA are also involved in the regulation of endocytic trafficking, it is therefore anticipated that DGKs also plays an important role in membrane trafficking. In this review, we summarize the literature discussing the role of DGK isoforms at different stages of endocytic trafficking, including endocytosis, exocytosis, endocytic recycling, and transport from/to the Golgi apparatus. Overall, these studies contribute to our understanding of the involvement of PA and DAG in endocytic trafficking, an area of research that is drawing increasing attention in recent years.",
keywords = "Diacylglycerol, Diacylglycerol kinase, Endocytic recycling, Golgi, Membrane trafficking, MICAL-L1, Phosphatidic acid",
author = "Shuwei Xie and Naava Naslavsky and Caplan, {Steven H}",
year = "2015",
month = "1",
day = "1",
doi = "10.1080/21592799.2015.1078431",
language = "English (US)",
volume = "5",
journal = "Cellular Logistics",
issn = "2159-2780",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - Diacylglycerol kinases in membrane trafficking

AU - Xie, Shuwei

AU - Naslavsky, Naava

AU - Caplan, Steven H

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity. These differences allow regulation of cellular responses by fine-tuning the delicate balance of cellular DAG and PA. DGK isoforms are best characterized as mediators of signal transduction and immune function. However, since recent studies reveal that DAG and PA are also involved in the regulation of endocytic trafficking, it is therefore anticipated that DGKs also plays an important role in membrane trafficking. In this review, we summarize the literature discussing the role of DGK isoforms at different stages of endocytic trafficking, including endocytosis, exocytosis, endocytic recycling, and transport from/to the Golgi apparatus. Overall, these studies contribute to our understanding of the involvement of PA and DAG in endocytic trafficking, an area of research that is drawing increasing attention in recent years.

AB - Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity. These differences allow regulation of cellular responses by fine-tuning the delicate balance of cellular DAG and PA. DGK isoforms are best characterized as mediators of signal transduction and immune function. However, since recent studies reveal that DAG and PA are also involved in the regulation of endocytic trafficking, it is therefore anticipated that DGKs also plays an important role in membrane trafficking. In this review, we summarize the literature discussing the role of DGK isoforms at different stages of endocytic trafficking, including endocytosis, exocytosis, endocytic recycling, and transport from/to the Golgi apparatus. Overall, these studies contribute to our understanding of the involvement of PA and DAG in endocytic trafficking, an area of research that is drawing increasing attention in recent years.

KW - Diacylglycerol

KW - Diacylglycerol kinase

KW - Endocytic recycling

KW - Golgi

KW - Membrane trafficking

KW - MICAL-L1

KW - Phosphatidic acid

UR - http://www.scopus.com/inward/record.url?scp=85011074978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011074978&partnerID=8YFLogxK

U2 - 10.1080/21592799.2015.1078431

DO - 10.1080/21592799.2015.1078431

M3 - Review article

VL - 5

JO - Cellular Logistics

JF - Cellular Logistics

SN - 2159-2780

IS - 2

ER -