Diabetic cataracts: Mechanisms and management

Irina G. Obrosova, Stephen S M Chung, Peter F Kador

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

Diabetes mellitus is associated with a 5-fold higher prevalence of cataracts, which remains a major cause of blindness in the world. Typical diabetic cataracts contain cortical and/or posterior subcapsular opacities. Adult onset diabetic cataracts also often contain nuclear opacities. Mechanisms of diabetic cataractogenesis have been studied in less detail than those of other diabetic complications. Both animal and human studies support important contribution of increased aldose reductase activity. Surgical extraction is the only cure of diabetic cataract today. An improved understanding of pathogenetic mechanisms, together with finding effective therapeutic agents, remain highest priority for diabetic cataract-related research and pharmaceutical development.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalDiabetes/Metabolism Research and Reviews
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2010

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Keywords

  • Anticataract agents
  • Diabetic cataract
  • Lens

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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