Diabetic and galactosaemic cataracts.

P. F. Kador, J. H. Kinoshita

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

An increased prevalence of cataract is associated with diabetes. Biochemical studies of diabetic lenses have revealed a variety of metabolic abnormalities including changes in the levels of electrolytes, glutathione, nucleotides and sugars. Similar biochemical changes have also been observed in cataracts associated with galactosaemia, suggesting that these sugar cataracts have a common biochemical aetiology. The common biochemical factor found to initiate both types of sugar cataract is the formation of sugar alcohols (polyols) from either glucose or galactose by the enzyme aldose reductase (alditol: NADP+ 1-oxidoreductase, EC 1.1.1.21). Increased intracellular levels of these polar alcohols have a hyperosmotic effect which leads to lens fibre swelling, vacuole formation and subsequent opacification. The process of sugar cataract formation in animals can be prevented by inhibiting aldose reductase.

Original languageEnglish (US)
Pages (from-to)110-131
Number of pages22
JournalCiba Foundation symposium
Volume106
StatePublished - Dec 1 1984

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Cataract
Sugar Alcohols
Aldehyde Reductase
Lenses
Galactosemias
Vacuoles
Galactose
NADP
Electrolytes
Glutathione
Oxidoreductases
Nucleotides
Alcohols
Glucose
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Diabetic and galactosaemic cataracts. / Kador, P. F.; Kinoshita, J. H.

In: Ciba Foundation symposium, Vol. 106, 01.12.1984, p. 110-131.

Research output: Contribution to journalReview article

Kador, PF & Kinoshita, JH 1984, 'Diabetic and galactosaemic cataracts.', Ciba Foundation symposium, vol. 106, pp. 110-131.
Kador, P. F. ; Kinoshita, J. H. / Diabetic and galactosaemic cataracts. In: Ciba Foundation symposium. 1984 ; Vol. 106. pp. 110-131.
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