Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use

Gabriel L. Schlomer, H. Harrington Cleveland, Arielle R. Deutsch, David J. Vandenbergh, Mark E. Feinberg, Mark T. Greenberg, Richard L. Spoth, Cleve Redmond

Research output: Contribution to journalArticle

Abstract

Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.

Original languageEnglish (US)
Pages (from-to)71-85
Number of pages15
JournalJournal of Youth and Adolescence
Volume48
Issue number1
DOIs
StatePublished - Jan 15 2019

Fingerprint

delinquency
alcohol
Alcohols
adolescent
Research
interaction
Gene-Environment Interaction
Caucasian
Haplotypes
Single Nucleotide Polymorphism
logistics
Alleles
time

Keywords

  • Delinquency
  • GABRA2
  • Genetic
  • GxE
  • Intervention

ASJC Scopus subject areas

  • Social Psychology
  • Education
  • Developmental and Educational Psychology
  • Social Sciences (miscellaneous)

Cite this

Developmental Change in Adolescent Delinquency : Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use. / Schlomer, Gabriel L.; Cleveland, H. Harrington; Deutsch, Arielle R.; Vandenbergh, David J.; Feinberg, Mark E.; Greenberg, Mark T.; Spoth, Richard L.; Redmond, Cleve.

In: Journal of Youth and Adolescence, Vol. 48, No. 1, 15.01.2019, p. 71-85.

Research output: Contribution to journalArticle

Schlomer, Gabriel L. ; Cleveland, H. Harrington ; Deutsch, Arielle R. ; Vandenbergh, David J. ; Feinberg, Mark E. ; Greenberg, Mark T. ; Spoth, Richard L. ; Redmond, Cleve. / Developmental Change in Adolescent Delinquency : Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use. In: Journal of Youth and Adolescence. 2019 ; Vol. 48, No. 1. pp. 71-85.
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