Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

Hugh De Lautour, William J. Taylor, Ade Adebajo, Rieke Alten, Ruben Burgos-Vargas, Peter Chapman, Marco A. Cimmino, Geraldo Da Rocha Castelar Pinheiro, Ric Day, Leslie R. Harrold, Philip Helliwell, Matthijs Janssen, Gail Kerr, Arthur Kavanaugh, Dinesh Khanna, Puja P. Khanna, Chingtsai Lin, Worawit Louthrenoo, Geraldine McCarthy, Janitzia Vazquez-MelladoTed R Mikuls, Tuhina Neogi, Alexis Ogdie, Fernando Perez-Ruiz, Naomi Schlesinger, H. Ralph Schumacher, Carlo A. Scirè, Jasvinder A. Singh, Francisca Sivera, Ole Slot, Lisa K. Stamp, Anne Kathrin Tausche, Robert Terkeltaub, Till Uhlig, Mart Van De Laar, Douglas White, Hisashi Yamanaka, Xuejun Zeng, Nicola Dalbeth

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (<0.36 mm), pain (<2 on a 10-point scale), and patient global assessment (<2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.

Original languageEnglish (US)
Pages (from-to)667-672
Number of pages6
JournalArthritis Care and Research
Volume68
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Gout
Consensus
Exercise
Uric Acid
Pain
Serum
Software
Clinical Trials
Surveys and Questionnaires

ASJC Scopus subject areas

  • Rheumatology

Cite this

De Lautour, H., Taylor, W. J., Adebajo, A., Alten, R., Burgos-Vargas, R., Chapman, P., ... Dalbeth, N. (2016). Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. Arthritis Care and Research, 68(5), 667-672. https://doi.org/10.1002/acr.22741

Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. / De Lautour, Hugh; Taylor, William J.; Adebajo, Ade; Alten, Rieke; Burgos-Vargas, Ruben; Chapman, Peter; Cimmino, Marco A.; Da Rocha Castelar Pinheiro, Geraldo; Day, Ric; Harrold, Leslie R.; Helliwell, Philip; Janssen, Matthijs; Kerr, Gail; Kavanaugh, Arthur; Khanna, Dinesh; Khanna, Puja P.; Lin, Chingtsai; Louthrenoo, Worawit; McCarthy, Geraldine; Vazquez-Mellado, Janitzia; Mikuls, Ted R; Neogi, Tuhina; Ogdie, Alexis; Perez-Ruiz, Fernando; Schlesinger, Naomi; Ralph Schumacher, H.; Scirè, Carlo A.; Singh, Jasvinder A.; Sivera, Francisca; Slot, Ole; Stamp, Lisa K.; Tausche, Anne Kathrin; Terkeltaub, Robert; Uhlig, Till; Van De Laar, Mart; White, Douglas; Yamanaka, Hisashi; Zeng, Xuejun; Dalbeth, Nicola.

In: Arthritis Care and Research, Vol. 68, No. 5, 01.05.2016, p. 667-672.

Research output: Contribution to journalArticle

De Lautour, H, Taylor, WJ, Adebajo, A, Alten, R, Burgos-Vargas, R, Chapman, P, Cimmino, MA, Da Rocha Castelar Pinheiro, G, Day, R, Harrold, LR, Helliwell, P, Janssen, M, Kerr, G, Kavanaugh, A, Khanna, D, Khanna, PP, Lin, C, Louthrenoo, W, McCarthy, G, Vazquez-Mellado, J, Mikuls, TR, Neogi, T, Ogdie, A, Perez-Ruiz, F, Schlesinger, N, Ralph Schumacher, H, Scirè, CA, Singh, JA, Sivera, F, Slot, O, Stamp, LK, Tausche, AK, Terkeltaub, R, Uhlig, T, Van De Laar, M, White, D, Yamanaka, H, Zeng, X & Dalbeth, N 2016, 'Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises', Arthritis Care and Research, vol. 68, no. 5, pp. 667-672. https://doi.org/10.1002/acr.22741
De Lautour H, Taylor WJ, Adebajo A, Alten R, Burgos-Vargas R, Chapman P et al. Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. Arthritis Care and Research. 2016 May 1;68(5):667-672. https://doi.org/10.1002/acr.22741
De Lautour, Hugh ; Taylor, William J. ; Adebajo, Ade ; Alten, Rieke ; Burgos-Vargas, Ruben ; Chapman, Peter ; Cimmino, Marco A. ; Da Rocha Castelar Pinheiro, Geraldo ; Day, Ric ; Harrold, Leslie R. ; Helliwell, Philip ; Janssen, Matthijs ; Kerr, Gail ; Kavanaugh, Arthur ; Khanna, Dinesh ; Khanna, Puja P. ; Lin, Chingtsai ; Louthrenoo, Worawit ; McCarthy, Geraldine ; Vazquez-Mellado, Janitzia ; Mikuls, Ted R ; Neogi, Tuhina ; Ogdie, Alexis ; Perez-Ruiz, Fernando ; Schlesinger, Naomi ; Ralph Schumacher, H. ; Scirè, Carlo A. ; Singh, Jasvinder A. ; Sivera, Francisca ; Slot, Ole ; Stamp, Lisa K. ; Tausche, Anne Kathrin ; Terkeltaub, Robert ; Uhlig, Till ; Van De Laar, Mart ; White, Douglas ; Yamanaka, Hisashi ; Zeng, Xuejun ; Dalbeth, Nicola. / Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. In: Arthritis Care and Research. 2016 ; Vol. 68, No. 5. pp. 667-672.
@article{7050db58d53b4e97968cc51c78a1a01c,
title = "Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises",
abstract = "Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56{\%} response) to the initial survey, with subsequent response rates ranging from 57{\%} to 90{\%}. Consensus was reached for the inclusion of serum urate (98{\%} agreement), flares (96{\%}), tophi (92{\%}), pain (83{\%}), and patient global assessment of disease activity (93{\%}) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (<0.36 mm), pain (<2 on a 10-point scale), and patient global assessment (<2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51{\%}) and 1 year (49{\%}). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.",
author = "{De Lautour}, Hugh and Taylor, {William J.} and Ade Adebajo and Rieke Alten and Ruben Burgos-Vargas and Peter Chapman and Cimmino, {Marco A.} and {Da Rocha Castelar Pinheiro}, Geraldo and Ric Day and Harrold, {Leslie R.} and Philip Helliwell and Matthijs Janssen and Gail Kerr and Arthur Kavanaugh and Dinesh Khanna and Khanna, {Puja P.} and Chingtsai Lin and Worawit Louthrenoo and Geraldine McCarthy and Janitzia Vazquez-Mellado and Mikuls, {Ted R} and Tuhina Neogi and Alexis Ogdie and Fernando Perez-Ruiz and Naomi Schlesinger and {Ralph Schumacher}, H. and Scir{\`e}, {Carlo A.} and Singh, {Jasvinder A.} and Francisca Sivera and Ole Slot and Stamp, {Lisa K.} and Tausche, {Anne Kathrin} and Robert Terkeltaub and Till Uhlig and {Van De Laar}, Mart and Douglas White and Hisashi Yamanaka and Xuejun Zeng and Nicola Dalbeth",
year = "2016",
month = "5",
day = "1",
doi = "10.1002/acr.22741",
language = "English (US)",
volume = "68",
pages = "667--672",
journal = "Arthritis and Rheumatism",
issn = "2151-4658",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

AU - De Lautour, Hugh

AU - Taylor, William J.

AU - Adebajo, Ade

AU - Alten, Rieke

AU - Burgos-Vargas, Ruben

AU - Chapman, Peter

AU - Cimmino, Marco A.

AU - Da Rocha Castelar Pinheiro, Geraldo

AU - Day, Ric

AU - Harrold, Leslie R.

AU - Helliwell, Philip

AU - Janssen, Matthijs

AU - Kerr, Gail

AU - Kavanaugh, Arthur

AU - Khanna, Dinesh

AU - Khanna, Puja P.

AU - Lin, Chingtsai

AU - Louthrenoo, Worawit

AU - McCarthy, Geraldine

AU - Vazquez-Mellado, Janitzia

AU - Mikuls, Ted R

AU - Neogi, Tuhina

AU - Ogdie, Alexis

AU - Perez-Ruiz, Fernando

AU - Schlesinger, Naomi

AU - Ralph Schumacher, H.

AU - Scirè, Carlo A.

AU - Singh, Jasvinder A.

AU - Sivera, Francisca

AU - Slot, Ole

AU - Stamp, Lisa K.

AU - Tausche, Anne Kathrin

AU - Terkeltaub, Robert

AU - Uhlig, Till

AU - Van De Laar, Mart

AU - White, Douglas

AU - Yamanaka, Hisashi

AU - Zeng, Xuejun

AU - Dalbeth, Nicola

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (<0.36 mm), pain (<2 on a 10-point scale), and patient global assessment (<2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.

AB - Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (<0.36 mm), pain (<2 on a 10-point scale), and patient global assessment (<2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.

UR - http://www.scopus.com/inward/record.url?scp=84964432661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964432661&partnerID=8YFLogxK

U2 - 10.1002/acr.22741

DO - 10.1002/acr.22741

M3 - Article

C2 - 26414176

AN - SCOPUS:84964432661

VL - 68

SP - 667

EP - 672

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

SN - 2151-4658

IS - 5

ER -