Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids

Yan Wang, Stuart T. Hazeldine, Jing Li, David Oupicky

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.

Original languageEnglish (US)
Pages (from-to)729-738
Number of pages10
JournalAdvanced Healthcare Materials
Volume4
Issue number5
DOIs
StatePublished - Apr 1 2015

Fingerprint

Chemokine Receptors
Nucleic acids
Nucleic Acids
CXCR4 Receptors
Amines
Leukocytes
Monomers
Functional polymers
Neoplasms
Bone
DNA
Blood
Cells
Transfection
Polymers
Bone Marrow
Pharmaceutical Preparations
Therapeutics

Keywords

  • Chemokine receptors
  • Gene delivery
  • Polycation
  • Polyplexes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids. / Wang, Yan; Hazeldine, Stuart T.; Li, Jing; Oupicky, David.

In: Advanced Healthcare Materials, Vol. 4, No. 5, 01.04.2015, p. 729-738.

Research output: Contribution to journalArticle

@article{1a3b252181044126be3bcbbd7ecf4b43,
title = "Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids",
abstract = "CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.",
keywords = "Chemokine receptors, Gene delivery, Polycation, Polyplexes",
author = "Yan Wang and Hazeldine, {Stuart T.} and Jing Li and David Oupicky",
year = "2015",
month = "4",
day = "1",
doi = "10.1002/adhm.201400608",
language = "English (US)",
volume = "4",
pages = "729--738",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids

AU - Wang, Yan

AU - Hazeldine, Stuart T.

AU - Li, Jing

AU - Oupicky, David

PY - 2015/4/1

Y1 - 2015/4/1

N2 - CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.

AB - CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.

KW - Chemokine receptors

KW - Gene delivery

KW - Polycation

KW - Polyplexes

UR - http://www.scopus.com/inward/record.url?scp=84928358014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928358014&partnerID=8YFLogxK

U2 - 10.1002/adhm.201400608

DO - 10.1002/adhm.201400608

M3 - Article

VL - 4

SP - 729

EP - 738

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 5

ER -