Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders

Dawn Eggert, Prasanta K. Dash, Nawal Serradji, Chang Zhi Dong, Pascal Clayette, Francoise Heymans, Huanyu Dou, Santhi Gorantla, Harris A. Gelbard, Larisa Y Poluektova, Howard Eliot Gendelman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The neuroregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former, PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders.

Original languageEnglish (US)
Pages (from-to)47-59
Number of pages13
JournalJournal of Neuroimmunology
Volume213
Issue number1-2
DOIs
StatePublished - Aug 18 2009

Fingerprint

Platelet Activating Factor
HIV-1
Encephalitis
SCID Mice
Giant Cells
Animal Models
Macrophages
PMS 601
Neurocognitive Disorders
Therapeutics

Keywords

  • Human immunodeficiency virus
  • Multinucleated giant cell
  • Nuclear factor kappa beta
  • PMS-601
  • Platelet activating factor
  • Proline-rich tyrosine kinase 2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. / Eggert, Dawn; Dash, Prasanta K.; Serradji, Nawal; Dong, Chang Zhi; Clayette, Pascal; Heymans, Francoise; Dou, Huanyu; Gorantla, Santhi; Gelbard, Harris A.; Poluektova, Larisa Y; Gendelman, Howard Eliot.

In: Journal of Neuroimmunology, Vol. 213, No. 1-2, 18.08.2009, p. 47-59.

Research output: Contribution to journalArticle

Eggert, Dawn ; Dash, Prasanta K. ; Serradji, Nawal ; Dong, Chang Zhi ; Clayette, Pascal ; Heymans, Francoise ; Dou, Huanyu ; Gorantla, Santhi ; Gelbard, Harris A. ; Poluektova, Larisa Y ; Gendelman, Howard Eliot. / Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. In: Journal of Neuroimmunology. 2009 ; Vol. 213, No. 1-2. pp. 47-59.
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