Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals

Brian Bewer, Honglin Zhang, Ying Zhu, Limei Zhang, Graham N. George, Ingrid J. Pickering, Dean Chapman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K -edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.

Original languageEnglish (US)
Article number085102
JournalReview of Scientific Instruments
Volume79
Issue number8
DOIs
StatePublished - Sep 8 2008

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subtraction
Imaging systems
animals
Animals
Fluorescence
Imaging techniques
fluorescence
pencil beams
Iodine
Photons
photon beams
Ionization chambers
Image acquisition
Microanalysis
iodine
CCD cameras
Germanium
Light sources
Detectors
Scanning

ASJC Scopus subject areas

  • Instrumentation

Cite this

Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals. / Bewer, Brian; Zhang, Honglin; Zhu, Ying; Zhang, Limei; George, Graham N.; Pickering, Ingrid J.; Chapman, Dean.

In: Review of Scientific Instruments, Vol. 79, No. 8, 085102, 08.09.2008.

Research output: Contribution to journalArticle

Bewer, Brian ; Zhang, Honglin ; Zhu, Ying ; Zhang, Limei ; George, Graham N. ; Pickering, Ingrid J. ; Chapman, Dean. / Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals. In: Review of Scientific Instruments. 2008 ; Vol. 79, No. 8.
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