Determination of the site of zinc absorption in rat small intestine

Dean Lowell Antonson, A. J. Barak, J. A. Vanderhoof

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The authors have studied net uptake of zinc from segments of rat duodenum, jejunum, and ileum using in vivo intestinal perfusion. We have also evaluated the effect of pancreatic and bile secretions on duodenal zinc absorption. Segments of duodenum, jejunum, and ileum and duodenum with bile and pancreatic duct obstruction, 10 cm in length, were studied in six rats each. Percentage absorption of zinc as determined by atomic absorption spectophotometry was greater from the ileum (60.1%) when compared to duodenum (19.1%) or jejunum (20.2%). Exclusion of bile and pancreatic secretions from the lumen increased zinc absorption in the duodenum (32.0%). Postperfusion mucosal zinc content comprised 29.0% of absorbed zinc from jejunum, 7.4% from ileum, 5.2% from duodenum, and 2.7% from duodenum with bile and pancreatic duct obstructed, indicating rapid transport of zinc across epithelial cells after uptake from the duodenum and ileum. The data indicate that the ileum has the greatest capacity for zinc absorption.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalJournal of Nutrition
Volume109
Issue number1
StatePublished - Jan 1 1979

Fingerprint

duodenum
Duodenum
Small Intestine
small intestine
Zinc
zinc
Ileum
ileum
rats
Jejunum
jejunum
pancreatic ducts
bile ducts
Pancreatic Ducts
Bile
bile secretion
uptake mechanisms
intestinal obstruction
Cholestasis
bile

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Antonson, D. L., Barak, A. J., & Vanderhoof, J. A. (1979). Determination of the site of zinc absorption in rat small intestine. Journal of Nutrition, 109(1), 142-147.

Determination of the site of zinc absorption in rat small intestine. / Antonson, Dean Lowell; Barak, A. J.; Vanderhoof, J. A.

In: Journal of Nutrition, Vol. 109, No. 1, 01.01.1979, p. 142-147.

Research output: Contribution to journalArticle

Antonson, DL, Barak, AJ & Vanderhoof, JA 1979, 'Determination of the site of zinc absorption in rat small intestine', Journal of Nutrition, vol. 109, no. 1, pp. 142-147.
Antonson DL, Barak AJ, Vanderhoof JA. Determination of the site of zinc absorption in rat small intestine. Journal of Nutrition. 1979 Jan 1;109(1):142-147.
Antonson, Dean Lowell ; Barak, A. J. ; Vanderhoof, J. A. / Determination of the site of zinc absorption in rat small intestine. In: Journal of Nutrition. 1979 ; Vol. 109, No. 1. pp. 142-147.
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