Determination of Minimal Residual Disease in Multiple Myeloma: Does It Matter?

Shalin Kothari, Jens Hillengass, Philip L. McCarthy, Sarah A. Holstein

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Purpose of Review: The ability to detect minimal residual disease (MRD) in myeloma has improved due to advances in flow cytometry and sequencing methodologies. Here, we evaluate recent clinical trial data and explore the current and future roles of MRD assessment in the context of clinical trial design and clinical practice. Recent Findings: A review of recent phase III studies reveals that achievement of MRD negativity is associated with improved progression-free survival (PFS) and/or overall survival (OS). Treatment arms that are more effective from a PFS or overall response rate perspective are also associated with superior MRD negativity rates. The current standard MRD methodologies are limited by requiring bone marrow samples and refinement of methodologies that can detect disease outside of the bone marrow is needed. Summary: Currently, MRD is a prognostic biomarker and further efforts are required to determine whether it can serve as a surrogate endpoint. The use of MRD status to guide treatment decisions is currently not recommended outside the confines of a clinical trial.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalCurrent Hematologic Malignancy Reports
Volume14
Issue number1
DOIs
StatePublished - Feb 15 2019

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Keywords

  • Minimal residual disease
  • Multiple myeloma
  • Overall survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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