Determination of immune memory to hepatitis B vaccination through early booster response in college students

Chyi Feng Jan, Kuo Chin Huang, Yin Chu Chien, Donald E. Greydanus, H. Dele Davies, Tai Yuan Chiu, Li Min Huang, Chien Jen Chen, Ding Shinn Chen

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Abstract

The long-term protection of hepatitis B (HB) vaccination has been debated for years. The purpose here was to evaluate the kinetic changes of antibody to HB surface antigen (anti-HBs) and define immune memory of the HB vaccine among college students who had previously received full neonatal immunization against HB. In all, 127 college students aged 18-23 years born after July 1984 who had completed HB vaccination and were seronegative for all three HB viral markers, including HB surface antigen (HBsAg), antibody to HB core protein (anti-HBc), and anti-HBs, were recruited. They received three doses of HB vaccine at enrollment, 1 month and 6 months after enrollment. Their anti-HBs titers were assayed at enrollment, 7-10 days, 1 month, 6 months, and 7 months following the first dose of HB vaccine. The anti-HBs seroprotective rates for subjects 7-10 days, 1 month, 6 months, and 7 months postvaccination were 20.5%, 75.6%, 94.5%, and 99.2%, respectively. Those who were seroprotective at 7 to 10 days after one dose of HB vaccine booster developed significantly higher levels of anti-HBs at 1 and 6 months than those not developing seroprotective anti-HBs response at an earlier timepoint. Conclusion: At least one-quarter of HB vaccinees have lost their immune memory to the HB vaccine when entering college. Immune memory to HB vaccine was identified by early seroconversion, which was present in only 20% of vaccinees in the present study. To ensure higher than 90% anti-HBs seroconversion rates, at least 2 doses of HB booster vaccines are recommended for at-risk youths who received complete HB vaccinations in neonatal or infant periods but are seronegative for HBsAg, anti-HBs, and anti-HBc in adolescence.

Original languageEnglish (US)
Pages (from-to)1547-1554
Number of pages8
JournalHepatology
Volume51
Issue number5
DOIs
StatePublished - May 1 2010

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Hepatitis B Vaccines
Hepatitis B
Vaccination
Students
Hepatitis B Surface Antigens
Hepatitis B Antibodies
Surface Antigens
Anti-Idiotypic Antibodies
Immunization
Proteins
Biomarkers
Antibodies

ASJC Scopus subject areas

  • Hepatology

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Jan, C. F., Huang, K. C., Chien, Y. C., Greydanus, D. E., Dele Davies, H., Chiu, T. Y., ... Chen, D. S. (2010). Determination of immune memory to hepatitis B vaccination through early booster response in college students. Hepatology, 51(5), 1547-1554. https://doi.org/10.1002/hep.23543

Determination of immune memory to hepatitis B vaccination through early booster response in college students. / Jan, Chyi Feng; Huang, Kuo Chin; Chien, Yin Chu; Greydanus, Donald E.; Dele Davies, H.; Chiu, Tai Yuan; Huang, Li Min; Chen, Chien Jen; Chen, Ding Shinn.

In: Hepatology, Vol. 51, No. 5, 01.05.2010, p. 1547-1554.

Research output: Contribution to journalArticle

Jan, CF, Huang, KC, Chien, YC, Greydanus, DE, Dele Davies, H, Chiu, TY, Huang, LM, Chen, CJ & Chen, DS 2010, 'Determination of immune memory to hepatitis B vaccination through early booster response in college students', Hepatology, vol. 51, no. 5, pp. 1547-1554. https://doi.org/10.1002/hep.23543
Jan, Chyi Feng ; Huang, Kuo Chin ; Chien, Yin Chu ; Greydanus, Donald E. ; Dele Davies, H. ; Chiu, Tai Yuan ; Huang, Li Min ; Chen, Chien Jen ; Chen, Ding Shinn. / Determination of immune memory to hepatitis B vaccination through early booster response in college students. In: Hepatology. 2010 ; Vol. 51, No. 5. pp. 1547-1554.
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abstract = "The long-term protection of hepatitis B (HB) vaccination has been debated for years. The purpose here was to evaluate the kinetic changes of antibody to HB surface antigen (anti-HBs) and define immune memory of the HB vaccine among college students who had previously received full neonatal immunization against HB. In all, 127 college students aged 18-23 years born after July 1984 who had completed HB vaccination and were seronegative for all three HB viral markers, including HB surface antigen (HBsAg), antibody to HB core protein (anti-HBc), and anti-HBs, were recruited. They received three doses of HB vaccine at enrollment, 1 month and 6 months after enrollment. Their anti-HBs titers were assayed at enrollment, 7-10 days, 1 month, 6 months, and 7 months following the first dose of HB vaccine. The anti-HBs seroprotective rates for subjects 7-10 days, 1 month, 6 months, and 7 months postvaccination were 20.5{\%}, 75.6{\%}, 94.5{\%}, and 99.2{\%}, respectively. Those who were seroprotective at 7 to 10 days after one dose of HB vaccine booster developed significantly higher levels of anti-HBs at 1 and 6 months than those not developing seroprotective anti-HBs response at an earlier timepoint. Conclusion: At least one-quarter of HB vaccinees have lost their immune memory to the HB vaccine when entering college. Immune memory to HB vaccine was identified by early seroconversion, which was present in only 20{\%} of vaccinees in the present study. To ensure higher than 90{\%} anti-HBs seroconversion rates, at least 2 doses of HB booster vaccines are recommended for at-risk youths who received complete HB vaccinations in neonatal or infant periods but are seronegative for HBsAg, anti-HBs, and anti-HBc in adolescence.",
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AB - The long-term protection of hepatitis B (HB) vaccination has been debated for years. The purpose here was to evaluate the kinetic changes of antibody to HB surface antigen (anti-HBs) and define immune memory of the HB vaccine among college students who had previously received full neonatal immunization against HB. In all, 127 college students aged 18-23 years born after July 1984 who had completed HB vaccination and were seronegative for all three HB viral markers, including HB surface antigen (HBsAg), antibody to HB core protein (anti-HBc), and anti-HBs, were recruited. They received three doses of HB vaccine at enrollment, 1 month and 6 months after enrollment. Their anti-HBs titers were assayed at enrollment, 7-10 days, 1 month, 6 months, and 7 months following the first dose of HB vaccine. The anti-HBs seroprotective rates for subjects 7-10 days, 1 month, 6 months, and 7 months postvaccination were 20.5%, 75.6%, 94.5%, and 99.2%, respectively. Those who were seroprotective at 7 to 10 days after one dose of HB vaccine booster developed significantly higher levels of anti-HBs at 1 and 6 months than those not developing seroprotective anti-HBs response at an earlier timepoint. Conclusion: At least one-quarter of HB vaccinees have lost their immune memory to the HB vaccine when entering college. Immune memory to HB vaccine was identified by early seroconversion, which was present in only 20% of vaccinees in the present study. To ensure higher than 90% anti-HBs seroconversion rates, at least 2 doses of HB booster vaccines are recommended for at-risk youths who received complete HB vaccinations in neonatal or infant periods but are seronegative for HBsAg, anti-HBs, and anti-HBc in adolescence.

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