Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria

Lofty John Anyanwu, Aminu Mohammad, Lawal Abdullahi, Aliyu Farinyaro, Stephen K Obaro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Intestinal perforation is a serious but poorly understood complication of typhoid fever. This study aims to determine the patient factors associated with postoperative morbidity and mortality. Methods: We retrospectively reviewed the records of all children presenting to our unit with typhoid intestinal perforation (TIP) between March 2009 and December 2013. The patients were grouped based on postoperative outcome status and were compared with respect to patient related variables, using chi square test. Multivariate analysis was performed using a binary logistic regression model. Significance was assigned to a p-value < 0.05. Results: The records of 129 children were analyzed. There were 78 (60.5%) boys and 51 (39.5%) girls. The male/female ratio was 1.53:1. Their ages ranged from 3 years to 13 years (mean 8.14 years; SD 2.61 years). A single intestinal perforation was seen in 73.4% (94/128) of them, while 26.6% (34/128) had two or more. Mortality rate was 10.9%. Multivariate analysis showed that multiple intestinal perforations significantly predicted postoperative mortality (p = 0.005) and development of postoperative fecal fistula (p = 0.013), while serum albumin < 32 g/L was a predictor of postoperative surgical site infection (p = 0.002). Conclusion: Multiple intestinal perforations, a postoperative fecal fistula and hypoalbuminemia adversely affected outcome in our patients. Level of evidence: III (Retrospective study). Type of study—Prognosis study.

Original languageEnglish (US)
Pages (from-to)847-852
Number of pages6
JournalJournal of pediatric surgery
Volume53
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Intestinal Perforation
Child Mortality
Typhoid Fever
Nigeria
Morbidity
Fistula
Mortality
Multivariate Analysis
Logistic Models
Surgical Wound Infection
Hypoalbuminemia
Chi-Square Distribution
Serum Albumin
Retrospective Studies

Keywords

  • Intestinal perforation
  • Postoperative fecal fistula
  • Serum albumin
  • Surgical site infection
  • Typhoid fever

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. / Anyanwu, Lofty John; Mohammad, Aminu; Abdullahi, Lawal; Farinyaro, Aliyu; Obaro, Stephen K.

In: Journal of pediatric surgery, Vol. 53, No. 4, 01.04.2018, p. 847-852.

Research output: Contribution to journalArticle

Anyanwu, Lofty John ; Mohammad, Aminu ; Abdullahi, Lawal ; Farinyaro, Aliyu ; Obaro, Stephen K. / Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. In: Journal of pediatric surgery. 2018 ; Vol. 53, No. 4. pp. 847-852.
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abstract = "Background: Intestinal perforation is a serious but poorly understood complication of typhoid fever. This study aims to determine the patient factors associated with postoperative morbidity and mortality. Methods: We retrospectively reviewed the records of all children presenting to our unit with typhoid intestinal perforation (TIP) between March 2009 and December 2013. The patients were grouped based on postoperative outcome status and were compared with respect to patient related variables, using chi square test. Multivariate analysis was performed using a binary logistic regression model. Significance was assigned to a p-value < 0.05. Results: The records of 129 children were analyzed. There were 78 (60.5{\%}) boys and 51 (39.5{\%}) girls. The male/female ratio was 1.53:1. Their ages ranged from 3 years to 13 years (mean 8.14 years; SD 2.61 years). A single intestinal perforation was seen in 73.4{\%} (94/128) of them, while 26.6{\%} (34/128) had two or more. Mortality rate was 10.9{\%}. Multivariate analysis showed that multiple intestinal perforations significantly predicted postoperative mortality (p = 0.005) and development of postoperative fecal fistula (p = 0.013), while serum albumin < 32 g/L was a predictor of postoperative surgical site infection (p = 0.002). Conclusion: Multiple intestinal perforations, a postoperative fecal fistula and hypoalbuminemia adversely affected outcome in our patients. Level of evidence: III (Retrospective study). Type of study—Prognosis study.",
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