Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: Demographics, lifestyle, genetics, and toxicity

Rick J. Jansen, Maria Argos, Lin Tong, Jiabei Li, Muhammad Rakibuz-Zaman, Md Tariqul Islam, Vesna Slavkovich, Alauddin Ahmed, Ana Navas-Acien, Faruque Parvez, Yu Chen, Mary V. Gamble, Joseph H. Graziano, Brandon L. Pierce, Habibul Ahsan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in arsenic metabolism capacity. Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal component (PC) analysis of arsenic species. Results: Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (second methylation step), and PC2 appears to represent capacity to convert iAs toMMA(first methylation step). PC1 was positively associated (P <0.05) with age, female sex, and BMI, while negatively associated with smoking, arsenic exposure, education, and land ownership. PC2 was positively associated with age and education but negatively associated with female sex and BMI. PC2 was positively associated with skin lesion status, while PC1 was not. 10q24.32/AS3MT region polymorphisms were strongly associated with PC1, but not PC2. Patterns of association for most variables were similar for PC1 and DMA%, and for PC2 and MMA% with the exception of arsenic exposure and SNP associations. Conclusions: Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions. Impact: This work enhances our understanding of arsenic metabolism kinetics and toxicity risk profiles.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number2
DOIs
StatePublished - Feb 2016

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Arsenic
Life Style
Demography
Methylation
Phenotype
Skin
Arsenicals
Education
Bangladesh
Ownership
Principal Component Analysis
Individuality
Carcinogens
Single Nucleotide Polymorphism
Longitudinal Studies
Smoking
Urine

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals : Demographics, lifestyle, genetics, and toxicity. / Jansen, Rick J.; Argos, Maria; Tong, Lin; Li, Jiabei; Rakibuz-Zaman, Muhammad; Islam, Md Tariqul; Slavkovich, Vesna; Ahmed, Alauddin; Navas-Acien, Ana; Parvez, Faruque; Chen, Yu; Gamble, Mary V.; Graziano, Joseph H.; Pierce, Brandon L.; Ahsan, Habibul.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 2, 02.2016, p. 381-390.

Research output: Contribution to journalArticle

Jansen, RJ, Argos, M, Tong, L, Li, J, Rakibuz-Zaman, M, Islam, MT, Slavkovich, V, Ahmed, A, Navas-Acien, A, Parvez, F, Chen, Y, Gamble, MV, Graziano, JH, Pierce, BL & Ahsan, H 2016, 'Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: Demographics, lifestyle, genetics, and toxicity', Cancer Epidemiology Biomarkers and Prevention, vol. 25, no. 2, pp. 381-390. https://doi.org/10.1158/1055-9965.EPI-15-0718
Jansen, Rick J. ; Argos, Maria ; Tong, Lin ; Li, Jiabei ; Rakibuz-Zaman, Muhammad ; Islam, Md Tariqul ; Slavkovich, Vesna ; Ahmed, Alauddin ; Navas-Acien, Ana ; Parvez, Faruque ; Chen, Yu ; Gamble, Mary V. ; Graziano, Joseph H. ; Pierce, Brandon L. ; Ahsan, Habibul. / Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals : Demographics, lifestyle, genetics, and toxicity. In: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, No. 2. pp. 381-390.
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abstract = "Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs{\%}, MMA{\%}, and DMA{\%}) varies across individuals, reflecting differences in arsenic metabolism capacity. Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal component (PC) analysis of arsenic species. Results: Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (second methylation step), and PC2 appears to represent capacity to convert iAs toMMA(first methylation step). PC1 was positively associated (P <0.05) with age, female sex, and BMI, while negatively associated with smoking, arsenic exposure, education, and land ownership. PC2 was positively associated with age and education but negatively associated with female sex and BMI. PC2 was positively associated with skin lesion status, while PC1 was not. 10q24.32/AS3MT region polymorphisms were strongly associated with PC1, but not PC2. Patterns of association for most variables were similar for PC1 and DMA{\%}, and for PC2 and MMA{\%} with the exception of arsenic exposure and SNP associations. Conclusions: Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions. Impact: This work enhances our understanding of arsenic metabolism kinetics and toxicity risk profiles.",
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AU - Argos, Maria

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AU - Li, Jiabei

AU - Rakibuz-Zaman, Muhammad

AU - Islam, Md Tariqul

AU - Slavkovich, Vesna

AU - Ahmed, Alauddin

AU - Navas-Acien, Ana

AU - Parvez, Faruque

AU - Chen, Yu

AU - Gamble, Mary V.

AU - Graziano, Joseph H.

AU - Pierce, Brandon L.

AU - Ahsan, Habibul

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N2 - Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in arsenic metabolism capacity. Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal component (PC) analysis of arsenic species. Results: Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (second methylation step), and PC2 appears to represent capacity to convert iAs toMMA(first methylation step). PC1 was positively associated (P <0.05) with age, female sex, and BMI, while negatively associated with smoking, arsenic exposure, education, and land ownership. PC2 was positively associated with age and education but negatively associated with female sex and BMI. PC2 was positively associated with skin lesion status, while PC1 was not. 10q24.32/AS3MT region polymorphisms were strongly associated with PC1, but not PC2. Patterns of association for most variables were similar for PC1 and DMA%, and for PC2 and MMA% with the exception of arsenic exposure and SNP associations. Conclusions: Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions. Impact: This work enhances our understanding of arsenic metabolism kinetics and toxicity risk profiles.

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