Detection of Metastatic Liver Disease

Use of Liver Scans and Biochemical Liver Tests

Margaret A. Tempero, Richard J. Petersen, Rowen K Zetterman, Henry M. Lemon, Jud Gurney

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The records of 94 patients with a known diagnosis of extrahepatic cancer having liver scan, biochemical liver tests (alkaline phosphatase, SGOT, lactic dehydrogenase, and bilirubin levels, and subsequent liver biopsy within a six-week period were reviewed. The sensitivity, specificity, and accuracy of the scan and biochemical tests in the detection of metastatic liver disease were calculated. The most sensitive single examination was the group of biochemical liver tests. Liver scans performed in the presence of normal biochemical test results were insensitive when compared with the liver scan alone or the liver scan in the presence of abnormal biochemical test results. The specificity and accuracy of all tests and test combinations were statistically equivalent. Screening for hepatic metastases in patients with cancer is best accomplished with the more sensitive and less expensive group of biochemical liver tests, reserving the liver scan for those patients with abnormal biochemical test results.

Original languageEnglish (US)
Pages (from-to)1329-1332
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume248
Issue number11
DOIs
StatePublished - Sep 17 1982

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Liver Diseases
Liver
Liver Neoplasms
Aspartate Aminotransferases
Bilirubin
Alkaline Phosphatase
Oxidoreductases
Milk
Neoplasm Metastasis
Biopsy
Sensitivity and Specificity
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Detection of Metastatic Liver Disease : Use of Liver Scans and Biochemical Liver Tests. / Tempero, Margaret A.; Petersen, Richard J.; Zetterman, Rowen K; Lemon, Henry M.; Gurney, Jud.

In: JAMA: The Journal of the American Medical Association, Vol. 248, No. 11, 17.09.1982, p. 1329-1332.

Research output: Contribution to journalArticle

Tempero, Margaret A. ; Petersen, Richard J. ; Zetterman, Rowen K ; Lemon, Henry M. ; Gurney, Jud. / Detection of Metastatic Liver Disease : Use of Liver Scans and Biochemical Liver Tests. In: JAMA: The Journal of the American Medical Association. 1982 ; Vol. 248, No. 11. pp. 1329-1332.
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