Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

Scott Koenig, Howard Eliot Gendelman, Jan M. Orenstein, Mauro C. Dal Canto, Gholam H. Pezeshkpour, Margaret Yungbluth, Frank Janotta, Allen Aksamit, Malcolm A. Martin, Anthony S. Fauci

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Abstract

One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

Original languageEnglish (US)
Pages (from-to)1089-1093
Number of pages5
JournalScience
Volume233
Issue number4768
DOIs
StatePublished - Jan 1 1986

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Brain Diseases
Acquired Immunodeficiency Syndrome
Macrophages
HIV
Brain
Viruses
Viral RNA
Retroviridae
Coculture Techniques
Transmission Electron Microscopy
Virion
In Situ Hybridization
Dementia
Immunohistochemistry

ASJC Scopus subject areas

  • General

Cite this

Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. H., Yungbluth, M., ... Fauci, A. S. (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science, 233(4768), 1089-1093. https://doi.org/10.1126/science.3016903

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. / Koenig, Scott; Gendelman, Howard Eliot; Orenstein, Jan M.; Dal Canto, Mauro C.; Pezeshkpour, Gholam H.; Yungbluth, Margaret; Janotta, Frank; Aksamit, Allen; Martin, Malcolm A.; Fauci, Anthony S.

In: Science, Vol. 233, No. 4768, 01.01.1986, p. 1089-1093.

Research output: Contribution to journalArticle

Koenig, S, Gendelman, HE, Orenstein, JM, Dal Canto, MC, Pezeshkpour, GH, Yungbluth, M, Janotta, F, Aksamit, A, Martin, MA & Fauci, AS 1986, 'Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy', Science, vol. 233, no. 4768, pp. 1089-1093. https://doi.org/10.1126/science.3016903
Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science. 1986 Jan 1;233(4768):1089-1093. https://doi.org/10.1126/science.3016903
Koenig, Scott ; Gendelman, Howard Eliot ; Orenstein, Jan M. ; Dal Canto, Mauro C. ; Pezeshkpour, Gholam H. ; Yungbluth, Margaret ; Janotta, Frank ; Aksamit, Allen ; Martin, Malcolm A. ; Fauci, Anthony S. / Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. In: Science. 1986 ; Vol. 233, No. 4768. pp. 1089-1093.
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