Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma

S. Bekri, J. Adélaide, S. Merscher, J. Grosgeorge, F. Caroli-Bosc, D. Perucca-Lostanlen, Philip M Kelley, M. J. Pébusque, C. Theillet, D. Birnbaum, P. Gaudray

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Abstract

Amplification of loci present on band q13 of human chromosome 11 is a feature of a subset of estrogen receptor positive breast carcinomas prone to metastasis. As many as five distinct amplification units have been described on 11q13. They include particularly a genomic area encompassing the GARP gene at 11q13.5→q14.1. We have reassessed our current knowledge of this region, located telomeric to CCND1 and EMS1, which is amplified in 7–10% of mammary tumors. The loose definition of the driving forces of these amplification events led us to map accurately the boundaries of the amplifiable region, and thus to contribute a physical and transcriptional map of a 3-Mb region of chromosome 11. Four new genes were placed on the regional map, namely CBP2, CLNSIA, UVRAG, and PAKl. We have narrowed the core of the 11q13→q14 amplicon to a 350-kb area encompassing D11S533, mostly on its telomeric side. The map reported here represents an indispensable step toward sequencing the entire region, and thus toward uncovering gene(s) which play(s) a critical role in breast cancer progression.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalCytogenetic and Genome Research
Volume79
Issue number1-2
DOIs
StatePublished - Jan 1 1997

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Chromosomes, Human, Pair 11
Breast Neoplasms
Genes
Human Chromosomes
Estrogen Receptors
Neoplasm Metastasis
colligin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Bekri, S., Adélaide, J., Merscher, S., Grosgeorge, J., Caroli-Bosc, F., Perucca-Lostanlen, D., ... Gaudray, P. (1997). Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. Cytogenetic and Genome Research, 79(1-2), 125-131. https://doi.org/10.1159/000134699

Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. / Bekri, S.; Adélaide, J.; Merscher, S.; Grosgeorge, J.; Caroli-Bosc, F.; Perucca-Lostanlen, D.; Kelley, Philip M; Pébusque, M. J.; Theillet, C.; Birnbaum, D.; Gaudray, P.

In: Cytogenetic and Genome Research, Vol. 79, No. 1-2, 01.01.1997, p. 125-131.

Research output: Contribution to journalArticle

Bekri, S, Adélaide, J, Merscher, S, Grosgeorge, J, Caroli-Bosc, F, Perucca-Lostanlen, D, Kelley, PM, Pébusque, MJ, Theillet, C, Birnbaum, D & Gaudray, P 1997, 'Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma', Cytogenetic and Genome Research, vol. 79, no. 1-2, pp. 125-131. https://doi.org/10.1159/000134699
Bekri S, Adélaide J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D et al. Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. Cytogenetic and Genome Research. 1997 Jan 1;79(1-2):125-131. https://doi.org/10.1159/000134699
Bekri, S. ; Adélaide, J. ; Merscher, S. ; Grosgeorge, J. ; Caroli-Bosc, F. ; Perucca-Lostanlen, D. ; Kelley, Philip M ; Pébusque, M. J. ; Theillet, C. ; Birnbaum, D. ; Gaudray, P. / Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. In: Cytogenetic and Genome Research. 1997 ; Vol. 79, No. 1-2. pp. 125-131.
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