Design and Validation of a Biosensor Implantation Capsule Robot

Wanchuan Xie, Weston M. Lewis, Jared Kaser, C. Ross Welch, Pengbo Li, Carl A Nelson, Vishal M Kothari, Benjamin S Terry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have proposed a long-term, noninvasive, nonrestrictive method of delivering and implanting a biosensor within the body via a swallowable implantation capsule robot (ICR). The design and preliminary validation of the ICR's primary subsystem - the sensor deployment system - is discussed and evidence is provided for major design choices. The purpose of the sensor deployment system is to adhere a small biosensor to the mucosa of the intestine long-term, and the modality was inspired by tapeworms and other organisms that employ a strategy of mechanical adhesion to soft tissue via the combined use of hooks or needles and suckers. Testing was performed to refine the design of the suction and needle attachment as well as the sensor ejection features of the ICR. An experiment was conducted in which needle sharpness, needle length, and vacuum volume were varied, and no statistically significant difference was observed. Finally, preliminary testing, coupled with prior work within a live porcine model, provided evidence that this is a promising approach for implanting a biosensor within the small intestine.

Original languageEnglish (US)
Article number081003
JournalJournal of Biomechanical Engineering
Volume139
Issue number8
DOIs
StatePublished - Aug 1 2017

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Biosensing Techniques
Biosensors
Needles
Capsules
Robots
Sensors
Cestoda
Hooks
Suction
Testing
Vacuum
Small Intestine
Intestines
Mucous Membrane
Swine
Adhesion
Tissue
Experiments

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Design and Validation of a Biosensor Implantation Capsule Robot. / Xie, Wanchuan; Lewis, Weston M.; Kaser, Jared; Ross Welch, C.; Li, Pengbo; Nelson, Carl A; Kothari, Vishal M; Terry, Benjamin S.

In: Journal of Biomechanical Engineering, Vol. 139, No. 8, 081003, 01.08.2017.

Research output: Contribution to journalArticle

Xie, Wanchuan ; Lewis, Weston M. ; Kaser, Jared ; Ross Welch, C. ; Li, Pengbo ; Nelson, Carl A ; Kothari, Vishal M ; Terry, Benjamin S. / Design and Validation of a Biosensor Implantation Capsule Robot. In: Journal of Biomechanical Engineering. 2017 ; Vol. 139, No. 8.
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