Design and synthesis of an activity-based probe template for protein kinases

Santosh Keshipeddy, Shi Yu, Nathan Hnatiuk, Martha Morton, Xudong Yao, Amy R. Howell

Research output: Contribution to journalArticle

Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.

Original languageEnglish (US)
Article numberD23809ST
Pages (from-to)521-524
Number of pages4
JournalSynlett
Issue number4
DOIs
StatePublished - Aug 13 2010

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Protein Kinases
Insulin Receptor
Phosphotransferases

Keywords

  • Activity-based probes
  • Addition reactions
  • Enones
  • Epoxides
  • Regioselectivity

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Keshipeddy, S., Yu, S., Hnatiuk, N., Morton, M., Yao, X., & Howell, A. R. (2010). Design and synthesis of an activity-based probe template for protein kinases. Synlett, (4), 521-524. [D23809ST]. https://doi.org/10.1055/s-0029-1218543

Design and synthesis of an activity-based probe template for protein kinases. / Keshipeddy, Santosh; Yu, Shi; Hnatiuk, Nathan; Morton, Martha; Yao, Xudong; Howell, Amy R.

In: Synlett, No. 4, D23809ST, 13.08.2010, p. 521-524.

Research output: Contribution to journalArticle

Keshipeddy, S, Yu, S, Hnatiuk, N, Morton, M, Yao, X & Howell, AR 2010, 'Design and synthesis of an activity-based probe template for protein kinases', Synlett, no. 4, D23809ST, pp. 521-524. https://doi.org/10.1055/s-0029-1218543
Keshipeddy S, Yu S, Hnatiuk N, Morton M, Yao X, Howell AR. Design and synthesis of an activity-based probe template for protein kinases. Synlett. 2010 Aug 13;(4):521-524. D23809ST. https://doi.org/10.1055/s-0029-1218543
Keshipeddy, Santosh ; Yu, Shi ; Hnatiuk, Nathan ; Morton, Martha ; Yao, Xudong ; Howell, Amy R. / Design and synthesis of an activity-based probe template for protein kinases. In: Synlett. 2010 ; No. 4. pp. 521-524.
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