Design and synthesis of an activity-based probe template for protein kinases

Santosh Keshipeddy, Shi Yu, Nathan Hnatiuk, Martha Morton, Xudong Yao, Amy R. Howell

Research output: Contribution to journalArticle

Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.

Original languageEnglish (US)
Article numberD23809ST
Pages (from-to)521-524
Number of pages4
JournalSynlett
Issue number4
DOIs
StatePublished - Aug 13 2010

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Keywords

  • Activity-based probes
  • Addition reactions
  • Enones
  • Epoxides
  • Regioselectivity

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Keshipeddy, S., Yu, S., Hnatiuk, N., Morton, M., Yao, X., & Howell, A. R. (2010). Design and synthesis of an activity-based probe template for protein kinases. Synlett, (4), 521-524. [D23809ST]. https://doi.org/10.1055/s-0029-1218543