Abstract
The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 712-713 |
| Number of pages | 2 |
| Journal | American Chemical Society, Polymer Preprints, Division of Polymer Chemistry |
| Volume | 41 |
| Issue number | 1 |
| State | Published - Mar 1 2000 |
| Event | The San Francisco Meeting - San Francisco, CA, USA Duration: Mar 26 2000 → Mar 31 2000 |
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ASJC Scopus subject areas
- Polymers and Plastics
Cite this
Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. / Kiser, Patrick F.; Thomas, Allen A.; Eichenbaum, Gary M.; Needham, David; Kim, Intae.
In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 41, No. 1, 01.03.2000, p. 712-713.Research output: Contribution to journal › Conference article
}
TY - JOUR
T1 - Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters
AU - Kiser, Patrick F.
AU - Thomas, Allen A.
AU - Eichenbaum, Gary M.
AU - Needham, David
AU - Kim, Intae
PY - 2000/3/1
Y1 - 2000/3/1
N2 - The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.
AB - The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=0033741021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033741021&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:0033741021
VL - 41
SP - 712
EP - 713
JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
SN - 0032-3934
IS - 1
ER -