Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

Sara Bagherifard, Ali Tamayol, Pooria Mostafalu, Mohsen Akbari, Mattia Comotto, Nasim Annabi, Masoumeh Ghaderi, Sameer Sonkusale, Mehmet R. Dokmeci, Ali Khademhosseini

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications. A wearable drug delivery system based on a hydrogel sheet containing thermo-responsive drug carriers interfaced with a flexible heater is engineered for topical applications. The platform maintains a conformal contact with skin and enables on demand and tunable drug delivery by controlling the hydrogel temperature. The release rates of various molecules with different sizes are studied. The system paves the way toward engineering smart wound dressings.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalAdvanced Healthcare Materials
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Hydrogel
Drug delivery
Hydrogels
Skin
Pharmaceutical Preparations
Molecules
Lab-On-A-Chip Devices
Intercellular Signaling Peptides and Proteins
Controlled drug delivery
Wounds and Injuries
Drug Carriers
Topical Administration
Microfluidics
Closed loop systems
Temperature
Drug Delivery Systems
Bandages
Molecular weight
Molecular Weight

Keywords

  • Drug delivery
  • Epidermal patches
  • Flexible electronics
  • Thermoresponsive particles
  • Wound dressings

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Bagherifard, S., Tamayol, A., Mostafalu, P., Akbari, M., Comotto, M., Annabi, N., ... Khademhosseini, A. (2016). Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery. Advanced Healthcare Materials, 5(1), 175-184. https://doi.org/10.1002/adhm.201500357

Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery. / Bagherifard, Sara; Tamayol, Ali; Mostafalu, Pooria; Akbari, Mohsen; Comotto, Mattia; Annabi, Nasim; Ghaderi, Masoumeh; Sonkusale, Sameer; Dokmeci, Mehmet R.; Khademhosseini, Ali.

In: Advanced Healthcare Materials, Vol. 5, No. 1, 01.01.2016, p. 175-184.

Research output: Contribution to journalArticle

Bagherifard, S, Tamayol, A, Mostafalu, P, Akbari, M, Comotto, M, Annabi, N, Ghaderi, M, Sonkusale, S, Dokmeci, MR & Khademhosseini, A 2016, 'Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery', Advanced Healthcare Materials, vol. 5, no. 1, pp. 175-184. https://doi.org/10.1002/adhm.201500357
Bagherifard, Sara ; Tamayol, Ali ; Mostafalu, Pooria ; Akbari, Mohsen ; Comotto, Mattia ; Annabi, Nasim ; Ghaderi, Masoumeh ; Sonkusale, Sameer ; Dokmeci, Mehmet R. ; Khademhosseini, Ali. / Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery. In: Advanced Healthcare Materials. 2016 ; Vol. 5, No. 1. pp. 175-184.
@article{26745b10a7574041a948201a8dda803a,
title = "Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery",
abstract = "Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications. A wearable drug delivery system based on a hydrogel sheet containing thermo-responsive drug carriers interfaced with a flexible heater is engineered for topical applications. The platform maintains a conformal contact with skin and enables on demand and tunable drug delivery by controlling the hydrogel temperature. The release rates of various molecules with different sizes are studied. The system paves the way toward engineering smart wound dressings.",
keywords = "Drug delivery, Epidermal patches, Flexible electronics, Thermoresponsive particles, Wound dressings",
author = "Sara Bagherifard and Ali Tamayol and Pooria Mostafalu and Mohsen Akbari and Mattia Comotto and Nasim Annabi and Masoumeh Ghaderi and Sameer Sonkusale and Dokmeci, {Mehmet R.} and Ali Khademhosseini",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/adhm.201500357",
language = "English (US)",
volume = "5",
pages = "175--184",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

AU - Bagherifard, Sara

AU - Tamayol, Ali

AU - Mostafalu, Pooria

AU - Akbari, Mohsen

AU - Comotto, Mattia

AU - Annabi, Nasim

AU - Ghaderi, Masoumeh

AU - Sonkusale, Sameer

AU - Dokmeci, Mehmet R.

AU - Khademhosseini, Ali

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications. A wearable drug delivery system based on a hydrogel sheet containing thermo-responsive drug carriers interfaced with a flexible heater is engineered for topical applications. The platform maintains a conformal contact with skin and enables on demand and tunable drug delivery by controlling the hydrogel temperature. The release rates of various molecules with different sizes are studied. The system paves the way toward engineering smart wound dressings.

AB - Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications. A wearable drug delivery system based on a hydrogel sheet containing thermo-responsive drug carriers interfaced with a flexible heater is engineered for topical applications. The platform maintains a conformal contact with skin and enables on demand and tunable drug delivery by controlling the hydrogel temperature. The release rates of various molecules with different sizes are studied. The system paves the way toward engineering smart wound dressings.

KW - Drug delivery

KW - Epidermal patches

KW - Flexible electronics

KW - Thermoresponsive particles

KW - Wound dressings

UR - http://www.scopus.com/inward/record.url?scp=84953835929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953835929&partnerID=8YFLogxK

U2 - 10.1002/adhm.201500357

DO - 10.1002/adhm.201500357

M3 - Article

C2 - 26501166

AN - SCOPUS:84953835929

VL - 5

SP - 175

EP - 184

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 1

ER -