Depressor effect of closed-loop chip system in spontaneously hypertensive rats

Xing Ya Gao, Xing Lin Huang, Hanjun Wang, Li Min Zhou, Yao Xu, Wei Wang, Guo Qing Zhu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We previously reported that a closed-loop chip system was designed to decrease arterial pressure in normal rabbits and rats. In the present study, the depressor effects of the chip system were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). The arterial pressure was recorded, sampled, operated and processed in the chip system. The chip system instantaneously controlled arterial pressure by stimulating the left aortic depressor nerve according to the feedback signals of arterial pressure. The closed-loop chip system effectively decreased mean arterial pressure (MAP) and heart rate (HR) in both SHR and WKY rats. It decreased the duration and the maximal MAP level of the pressor response evoked by either intravenous injection of phenylephrine or cutaneous nociceptive stimulation in SHR, but had no significant effect on the magnitude of the increase in MAP. Furthermore, the chip system significantly increased the baroreflex gain in SHR, but not in normal WKY rats. These results suggest that the closed-loop chip system effectively decreases the arterial pressure and increases baroreflex gain in SHR. The chip system does not abolish the arterial pressure responses to accidental pressor events, but decreases the duration and the maximal MAP level of the pressor responses.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Volume137
Issue number1-2
DOIs
StatePublished - Dec 30 2007
Externally publishedYes

Fingerprint

Inbred SHR Rats
Arterial Pressure
Inbred WKY Rats
Baroreflex
Phenylephrine
Intravenous Injections
Heart Rate
Rabbits
Skin

Keywords

  • Baroreflex
  • Blood pressure
  • Chip
  • Hypertension

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Depressor effect of closed-loop chip system in spontaneously hypertensive rats. / Gao, Xing Ya; Huang, Xing Lin; Wang, Hanjun; Zhou, Li Min; Xu, Yao; Wang, Wei; Zhu, Guo Qing.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 137, No. 1-2, 30.12.2007, p. 84-91.

Research output: Contribution to journalArticle

Gao, Xing Ya ; Huang, Xing Lin ; Wang, Hanjun ; Zhou, Li Min ; Xu, Yao ; Wang, Wei ; Zhu, Guo Qing. / Depressor effect of closed-loop chip system in spontaneously hypertensive rats. In: Autonomic Neuroscience: Basic and Clinical. 2007 ; Vol. 137, No. 1-2. pp. 84-91.
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